PRPSAP2 explained

Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.^[1]

Function

The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of phosphoribosyl pyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS.^[1]

Further reading

• Katashima R, Iwahana H, Fujimura M, etal . Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein. . Biochim. Biophys. Acta . 1396 . 3 . 245–50 . 1998 . 9545573 . 10.1016/S0167-4781(97)00217-0.
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Katashima R, Iwahana H, Fujimura M, etal . Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12. . Genomics . 54 . 1 . 180–1 . 1998 . 9806849 . 10.1006/geno.1998.5432 .
• Low SK, Kuchiba A, Zembutsu H, etal . Genome-wide association study of pancreatic cancer in Japanese population. . PLOS ONE . 5 . 7 . e11824 . 2010 . 20686608 . 10.1371/journal.pone.0011824 . 2912284. 2010PLoSO...511824L . free .

Notes and References

1. Web site: Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2. 2011-08-30.