PRPF4B explained

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[1] [2] [3]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).

Interactions

PRPF4B has been shown to interact with Pinin.[4]

Further reading

Notes and References

  1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
  2. Kojima T, Zama T, Wada K, Onogi H, Hagiwara M . Cloning of human PRP4 reveals interaction with Clk1 . J Biol Chem . 276 . 34 . 32247–56 . Aug 2001 . 11418604 . 10.1074/jbc.M103790200 . free .
  3. Web site: Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast).
  4. Dellaire . Graham . Makarov Evgeny M . Cowger Jeff J M . Longman Dasa . Sutherland Heidi G E . Lührmann Reinhard . Torchia Joseph . Bickmore Wendy A . Jul 2002 . Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes . Mol. Cell. Biol. . 22 . 14 . 5141–56 . United States. 0270-7306. 12077342 . 10.1128/MCB.22.14.5141-5156.2002 . 139773 . 11858/00-001M-0000-0029-BC76-A.