PRPF4B explained
Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[1] [2] [3]
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).
Interactions
PRPF4B has been shown to interact with Pinin.[4]
Further reading
- Schultz SJ, Nigg EA . Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans . Cell Growth Differ. . 4 . 10 . 821–30 . 1994 . 8274451 .
- Gross T, Lützelberger M, Weigmann H, etal . Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue . Nucleic Acids Res. . 25 . 5 . 1028–35 . 1997 . 9102632 . 10.1093/nar/25.5.1028 . 146536 .
- Huang Y, Deng T, Winston BW . Characterization of hPRP4 kinase activation: potential role in signaling . Biochem. Biophys. Res. Commun. . 271 . 2 . 456–63 . 2000 . 10799319 . 10.1006/bbrc.2000.2651 .
- Jurica MS, Licklider LJ, Gygi SR, etal . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 .
- Dellaire G, Makarov EM, Cowger JJ, etal . Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes . Mol. Cell. Biol. . 22 . 14 . 5141–56 . 2002 . 12077342 . 10.1128/MCB.22.14.5141-5156.2002 . 139773 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
- Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
- Bennett EM, Lever AM, Allen JF . Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2 . J. Virol. . 78 . 20 . 11303–12 . 2004 . 15452250 . 10.1128/JVI.78.20.11303-11312.2004 . 521795 .
- Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
- Zhang Y, Wolf-Yadlin A, Ross PL, etal . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . free .
- Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
- Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
- Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
- Huang B, Ahn YT, McPherson L, etal . Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription . J. Immunol. . 178 . 11 . 7081–7 . 2007 . 17513757 . 10.4049/jimmunol.178.11.7081. 2674583 .
Notes and References
- Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
- Kojima T, Zama T, Wada K, Onogi H, Hagiwara M . Cloning of human PRP4 reveals interaction with Clk1 . J Biol Chem . 276 . 34 . 32247–56 . Aug 2001 . 11418604 . 10.1074/jbc.M103790200 . free .
- Web site: Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast).
- Dellaire . Graham . Makarov Evgeny M . Cowger Jeff J M . Longman Dasa . Sutherland Heidi G E . Lührmann Reinhard . Torchia Joseph . Bickmore Wendy A . Jul 2002 . Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes . Mol. Cell. Biol. . 22 . 14 . 5141–56 . United States. 0270-7306. 12077342 . 10.1128/MCB.22.14.5141-5156.2002 . 139773 . 11858/00-001M-0000-0029-BC76-A.