PRPF19 explained

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.^{[1] [2]}

In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]

Interactions

PRPF19 has been shown to interact with CDC5L.^[3]

Further reading

• Gerner C, Holzmann K, Meissner M, etal . Reassembling proteins and chaperones in human nuclear matrix protein fractions. . J. Cell. Biochem. . 74 . 2 . 145–51 . 1999 . 10404385 . 10.1002/(SICI)1097-4644(19990801)74:2<145::AID-JCB1>3.0.CO;2-# . 196598497 .
• Gotzmann J, Gerner C, Meissner M, etal . hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. . Exp. Cell Res. . 261 . 1 . 166–79 . 2000 . 11082287 . 10.1006/excr.2000.5025 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Jurica MS, Licklider LJ, Gygi SR, etal . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 .
• Scherl A, Couté Y, Déon C, etal . Functional proteomic analysis of human nucleolus. . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Makarova OV, Makarov EM, Urlaub H, etal . A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. . EMBO J. . 23 . 12 . 2381–91 . 2004 . 15175653 . 10.1038/sj.emboj.7600241 . 423283 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Löscher M, Fortschegger K, Ritter G, etal . Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. . Biochem. J. . 388 . Pt 2 . 593–603 . 2005 . 15660529 . 10.1042/BJ20041517 . 1138967 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Zhang N, Kaur R, Lu X, etal . The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. . J. Biol. Chem. . 280 . 49 . 40559–67 . 2006 . 16223718 . 10.1074/jbc.M508453200 . free .
• Grillari J, Ajuh P, Stadler G, etal . SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. . Nucleic Acids Res. . 33 . 21 . 6868–83 . 2005 . 16332694 . 10.1093/nar/gki986 . 1310963 .
• Voglauer R, Chang MW, Dampier B, etal . SNEV overexpression extends the life span of human endothelial cells. . Exp. Cell Res. . 312 . 6 . 746–59 . 2006 . 16388800 . 10.1016/j.yexcr.2005.11.025 .
• Lu X, Legerski RJ . The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage. . Biochem. Biophys. Res. Commun. . 354 . 4 . 968–74 . 2007 . 17276391 . 10.1016/j.bbrc.2007.01.097 . 1810354 .
• Fortschegger K, Wagner B, Voglauer R, etal . Early embryonic lethality of mice lacking the essential protein SNEV. . Mol. Cell. Biol. . 27 . 8 . 3123–30 . 2007 . 17283042 . 10.1128/MCB.01188-06 . 1899945 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Mahajan KN, Mitchell BS . Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase . Proc Natl Acad Sci U S A . 100 . 19 . 10746–51 . September 2003 . 12960389 . 196874 . 10.1073/pnas.1631060100 . 2003PNAS..10010746M . free .
2. Web site: Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae).
3. Ajuh . P . Kuster B . Panov K . Zomerdijk J C . Mann M . Lamond A I . December 2000 . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . EMBO J. . 19 . 23 . 6569–81 . 0261-4189. 11101529 . 10.1093/emboj/19.23.6569 . 305846 .