PRMT8 explained

Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene.^[1] Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization.^[1] PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.^[2]

Further reading

• Pahlich . S. . Zakaryan . R. P. . Gehring . H. . 10.1002/prot.22004 . Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state . Proteins: Structure, Function, and Bioinformatics . 72 . 4 . 1125–1137 . 2008 . 18320585 . 206402713 .
• Sayegh . J. . Webb . K. . Cheng . D. . Bedford . M. T. . Clarke . S. G. . Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain . 10.1074/jbc.M704650200 . Journal of Biological Chemistry . 282 . 50 . 36444–36453 . 2007 . 17925405 . free .

Notes and References

1. Web site: Protein arginine methyltransferase 8. 2011-12-04.
2. Kim . J. D. . Kako . K. . Kakiuchi . M. . Park . G. G. . Fukamizu . A. . EWS is a substrate of type I protein arginine methyltransferase, PRMT8 . International Journal of Molecular Medicine . 22 . 3 . 309–315 . 2008 . 18698489.