PRMT7 explained

Protein arginine methyltransferase 7 (PRMT7) is a protein that in humans is encoded by the PRMT7 gene.^[1] Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PRMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing.^{[1] [2]}

PRMT7 was initially identified as a Type II protein lysine methyltransferase, indicating its role in the symmetric dimethylation of arginine residues. However, it was later reclassified as a Type III protein lysine methyltransferase, meaning it facilitates the mono-methylation of arginine residues. As of 2023, PRMT7 remains the sole member of the Type III PRMT category.^[3]

Further reading

• Jelinic . P. . Stehle . J. C. . Shaw . P. . 10.1371/journal.pbio.0040355 . The Testis-Specific Factor CTCFL Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation . PLOS Biology . 4 . 11 . e355 . 2006 . 17048991 . 1609128 . free .
• Lee . J. -H. . Cook . J. R. . Yang . Z. H. . Mirochnitchenko . O. . Gunderson . S. I. . Felix . A. M. . Herth . N. . Hoffmann . R. . Pestka . S. . PRMT7, a New Protein Arginine Methyltransferase That Synthesizes Symmetric Dimethylarginine . 10.1074/jbc.M405295200 . Journal of Biological Chemistry . 280 . 5 . 3656–3664 . 2004 . 15494416 . free .
• Gonsalvez . G. B. . Tian . L. . Ospina . J. K. . Boisvert . F. -M. . Lamond . A. I. . Matera . A. G. . 10.1083/jcb.200702147 . Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins . The Journal of Cell Biology . 178 . 5 . 733–740 . 2007 . 17709427 . 2064538 .

Notes and References

1. Web site: Protein arginine methyltransferase 7. 2011-12-06.
2. Miranda . T. B. . Miranda . M. . Frankel . A. . Clarke . S. . PRMT7 is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity . 10.1074/jbc.M312904200 . Journal of Biological Chemistry . 279 . 22 . 22902–22907 . 2004 . 15044439 . free .
3. Book: Handbook of epigenetics: the new molecular and medical genetics . 2023 . Academic Press, an imprint of Elseiver . 978-0-323-91909-8 . Tollefsbol . Trygve O. . Third . London, United Kingdom ; San Diego, CA . 36.