PRMT6 explained

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.^{[1] [2]}

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Boulanger MC, Liang C, Russell RS, etal . Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression . J. Virol. . 79 . 1 . 124–31 . 2005 . 15596808 . 10.1128/JVI.79.1.124-131.2005 . 538702 .
• Sgarra R, Lee J, Tessari MA, etal . The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6 . J. Biol. Chem. . 281 . 7 . 3764–72 . 2006 . 16293633 . 10.1074/jbc.M510231200 . free . 11577/1565364 . free .
• Willemsen NM, Hitchen EM, Bodetti TJ, etal . Protein methylation is required to maintain optimal HIV-1 infectivity . Retrovirology . 3 . 92 . 2007 . 17169163 . 10.1186/1742-4690-3-92 . 1766367 . free .
• Invernizzi CF, Xie B, Richard S, Wainberg MA . PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA . Retrovirology . 3 . 93 . 2007 . 17176473 . 10.1186/1742-4690-3-93 . 1779295 . free .
• Xie B, Invernizzi CF, Richard S, Wainberg MA . Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region . J. Virol. . 81 . 8 . 4226–34 . 2007 . 17267505 . 10.1128/JVI.01888-06 . 1866113 .
• Guccione E, Bassi C, Casadio F, etal . Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive . Nature . 449 . 7164 . 933–7 . 2007 . 17898714 . 10.1038/nature06166 . 2007Natur.449..933G . 4341782 .

Notes and References

1. Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT . The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity . J Biol Chem . 277 . 5 . 3537–43 . Jan 2002 . 11724789 . 10.1074/jbc.M108786200 . free .
2. Web site: Entrez Gene: PRMT6 protein arginine methyltransferase 6.