PRMT3 explained
Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.[1] [2]
Interactions
PRMT3 has been shown to interact with RPS2.[3]
Further reading
- Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, Gutmann DH, Herschman HR, Clarke S, Newsham IF . 6 . DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo . Oncogene . 23 . 47 . 7761–71 . October 2004 . 15334060 . 10.1038/sj.onc.1208057 . free .
- Bachand F, Silver PA . PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits . The EMBO Journal . 23 . 13 . 2641–50 . July 2004 . 15175657 . 449775 . 10.1038/sj.emboj.7600265 .
- Smith JJ, Rücknagel KP, Schierhorn A, Tang J, Nemeth A, Linder M, Herschman HR, Wahle E . 6 . Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3 . The Journal of Biological Chemistry . 274 . 19 . 13229–34 . May 1999 . 10224081 . 10.1074/jbc.274.19.13229 . free .
Notes and References
- Tang J, Gary JD, Clarke S, Herschman HR . PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation . The Journal of Biological Chemistry . 273 . 27 . 16935–45 . July 1998 . 9642256 . 10.1074/jbc.273.27.16935 . free .
- Web site: Entrez Gene: PRMT3 protein arginine methyltransferase 3.
- Choi S, Jung CR, Kim JY, Im DS . PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex . Biochimica et Biophysica Acta (BBA) - General Subjects . 1780 . 9 . 1062–9 . September 2008 . 18573314 . 10.1016/j.bbagen.2008.05.010 .
