PRMT2 explained

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.^{[1] [2]}

Functions

The enzyme methylates final nitrogen atom of arginine residue in some proteins. It transfers two methyl groups from S-adenosyl-L-methionine.

Interactions

PRMT2 has been shown to interact with Estrogen receptor alpha^[3] and HNRPUL1.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
• Yu W . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Katsanis N, Yaspo ML, Fisher EM . Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene . Mamm. Genome . 8 . 7 . 526–9 . 1997 . 9196002 . 10.1007/s003359900491 . 32074112 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Hattori M . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . vanc. Fujiyama A . Taylor TD . 3 . Taylor . T. D. . Watanabe . H. . Yada . T. . Park . H.-S. . Toyoda . A. . Ishii . K. . free . 2000Natur.405..311H .
• Kzhyshkowska J . Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 . Biochem. J. . 358 . Pt 2 . 305–14 . 2001 . 11513728 . 10.1042/0264-6021:3580305 . 1222062 . vanc. Schütt H . Liss M . 3 . Kremmer . Elisabeth . Stauber . Roland . Wolf . Hans . Dobner . Thomas .
• Qi C . Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha . J. Biol. Chem. . 277 . 32 . 28624–30 . 2002 . 12039952 . 10.1074/jbc.M201053200 . vanc. Chang J . Zhu Y . 3 . Yeldandi . AV . Rao . SM . Zhu . YJ . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Lehner B . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . vanc. Semple JI . Brown SE . 3 . Counsell . Damian . Campbell . R.Duncan . Sanderson . Christopher M .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R. 4427026 .
• Ganesh L . Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis . Mol. Cell. Biol. . 26 . 10 . 3864–74 . 2006 . 16648481 . 10.1128/MCB.26.10.3864-3874.2006 . 1488990 . vanc. Yoshimoto T . Moorthy NC . 3 . Akahata . W. . Boehm . M. . Nabel . E. G. . Nabel . G. J. .

Notes and References

1. Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF . Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2) . Genomics . 48 . 3 . 330–40 . Jun 1998 . 9545638 . 10.1006/geno.1997.5190 .
2. Web site: Entrez Gene: PRMT2 protein arginine methyltransferase 2.
3. Qi . Chao . Chang Jeffrey . Zhu Yiwei . Yeldandi Anjana V . Rao Sambasiva M . Zhu Yi-Jun . Aug 2002 . Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha . J. Biol. Chem. . 277 . 32 . 28624–30 . United States. 0021-9258. 12039952 . 10.1074/jbc.M201053200 . free .
4. Kzhyshkowska . J . Schütt H . Liss M . Kremmer E . Stauber R . Wolf H . Dobner T . Sep 2001 . Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 . Biochem. J. . 358 . Pt 2 . 305–14 . England. 0264-6021. 11513728 . 10.1042/0264-6021:3580305 . 1222062 .