PRKRIR explained

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.^{[1] [2]}

Interactions

PRKRIR has been shown to interact with STK4^[3] and DNAJC3.

Further reading

• Mellor H, Proud CG . A synthetic peptide substrate for initiation factor-2 kinases. . Biochem. Biophys. Res. Commun. . 178 . 2 . 430–7 . 1991 . 1677563 . 10.1016/0006-291X(91)90125-Q .
• Polyak SJ, Tang N, Wambach M, etal . The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. . J. Biol. Chem. . 271 . 3 . 1702–7 . 1996 . 8576172 . 10.1074/jbc.271.3.1702 . free .
• Shi Y, Vattem KM, Sood R, etal . Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. . Mol. Cell. Biol. . 18 . 12 . 7499–509 . 1998 . 9819435 . 10.1128/MCB.18.12.7499. 109330 .
• Lu J, O'Hara EB, Trieselmann BA, etal . The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. . J. Biol. Chem. . 274 . 45 . 32198–203 . 1999 . 10542257 . 10.1074/jbc.274.45.32198 . free .
• Saelens X, Kalai M, Vandenabeele P . Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. . J. Biol. Chem. . 276 . 45 . 41620–8 . 2001 . 11555640 . 10.1074/jbc.M103674200 . free .
• Lin Y, Khokhlatchev A, Figeys D, Avruch J . Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. . J. Biol. Chem. . 277 . 50 . 47991–8001 . 2003 . 12384512 . 10.1074/jbc.M202630200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lee JH, Choi SR, Hwang TH, etal . A gene expression in study human gastric adenocarcinoma using a cDNA microarray. . The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi . 42 . 6 . 484–95 . 2004 . 14695705 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Gale M Jr . Blakely CM . Hopkins DA . Melville MW . Wambach M . Romano PR . Katze MG . Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK . Mol Cell Biol . 18 . 2 . 859–71 . Feb 1998 . 9447982 . 108797 . 10.1128/mcb.18.2.859.
2. Web site: Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor).
3. Lin . Yenshou . Khokhlatchev Andrei . Figeys Daniel . Avruch Joseph . Dec 2002 . Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis . J. Biol. Chem. . 277 . 50 . 47991–8001 . United States. 0021-9258. 12384512 . 10.1074/jbc.M202630200 . free .