PRKG1 explained

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.^{[1] [2] [3]}

Interactions

PRKG1 has been shown to interact with:

• GTF2I,^[4]
• ITPR1,^[5]
• MRVI1,^{[5] [6]}
• RGS2,^[7] and
• TNNT1.^[8]

Further reading

• Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC . Phosphorylation of the cystic fibrosis transmembrane conductance regulator . The Journal of Biological Chemistry . 267 . 18 . 12742–52 . Jun 1992 . 10.1016/S0021-9258(18)42339-3 . 1377674 . free .
• Thomas MK, Francis SH, Corbin JD . Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP . The Journal of Biological Chemistry . 265 . 25 . 14971–8 . Sep 1990 . 10.1016/S0021-9258(18)77211-6 . 2168396 . free .
• Pöhler D, Butt E, Meissner J, Müller S, Lohse M, Walter U, Lohmann SM, Jarchau T . Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system . FEBS Letters . 374 . 3 . 419–25 . Nov 1995 . 7589584 . 10.1016/0014-5793(95)01168-E . 25634004 . free .
• Komalavilas P, Lincoln TM . Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase . The Journal of Biological Chemistry . 269 . 12 . 8701–7 . Mar 1994 . 10.1016/S0021-9258(17)37024-2 . 8132598 . free .
• Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U . cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets . The Journal of Biological Chemistry . 269 . 20 . 14509–17 . May 1994 . 10.1016/S0021-9258(17)36652-8 . 8182057 . free .
• Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G . Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1175 . 2 . 193–206 . Jan 1993 . 8380342 . 10.1016/0167-4889(93)90023-I .
• Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun TH, Suga S, Yoshimasa T, Nakao K . cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase . Hypertension . 27 . 3 Pt 2 . 552–7 . Mar 1996 . 8613202 . 10.1161/01.hyp.27.3.552 .
• Salih E, Zhou HY, Glimcher MJ . Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases . The Journal of Biological Chemistry . 271 . 28 . 16897–905 . Jul 1996 . 8663267 . 10.1074/jbc.271.28.16897 . free .
• Xing J, Ginty DD, Greenberg ME . Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase . Science . 273 . 5277 . 959–63 . Aug 1996 . 8688081 . 10.1126/science.273.5277.959 . 1996Sci...273..959X . 22226803 .
• Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M . Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1) . Genomics . 42 . 2 . 311–8 . Jun 1997 . 9192852 . 10.1006/geno.1997.4743 .
• Deak M, Clifton AD, Lucocq LM, Alessi DR . Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB . The EMBO Journal . 17 . 15 . 4426–41 . Aug 1998 . 9687510 . 1170775 . 10.1093/emboj/17.15.4426 .
• Du K, Montminy M . CREB is a regulatory target for the protein kinase Akt/PKB . The Journal of Biological Chemistry . 273 . 49 . 32377–9 . Dec 1998 . 9829964 . 10.1074/jbc.273.49.32377 . free .
• Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M . Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 5 . 2467–72 . Mar 1999 . 10051666 . 26808 . 10.1073/pnas.96.5.2467 . 1999PNAS...96.2467E . free .
• Wang X, Bruderer S, Rafi Z, Xue J, Milburn PJ, Krämer A, Robinson PJ . Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly . The EMBO Journal . 18 . 16 . 4549–59 . Aug 1999 . 10449420 . 1171529 . 10.1093/emboj/18.16.4549 .
• Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, Mendelsohn ME . Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha . Science . 286 . 5444 . 1583–7 . Nov 1999 . 10567269 . 10.1126/science.286.5444.1583 .
• Yuasa K, Michibata H, Omori K, Yanaka N . A novel interaction of cGMP-dependent protein kinase I with troponin T . The Journal of Biological Chemistry . 274 . 52 . 37429–34 . Dec 1999 . 10601315 . 10.1074/jbc.274.52.37429 . free .
• Yuasa K, Omori K, Yanaka N . Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha . The Journal of Biological Chemistry . 275 . 7 . 4897–905 . Feb 2000 . 10671526 . 10.1074/jbc.275.7.4897 . free.
• Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD . Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle . The Journal of Biological Chemistry . 275 . 8 . 5504–11 . Feb 2000 . 10681529 . 10.1074/jbc.275.8.5504 . free .

Notes and References

1. Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T . Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat . FEBS Letters . 255 . 2 . 321–9 . Sep 1989 . 2792381 . 10.1016/0014-5793(89)81114-7 . 83233954 .
2. Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T . Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10 . Cytogenetics and Cell Genetics . 59 . 4 . 270–3 . April 1992 . 1544322 . 10.1159/000133267 .
3. Web site: Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I.
4. Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB . cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I . The Journal of Biological Chemistry . 277 . 35 . 32003–14 . Aug 2002 . 12082086 . 10.1074/jbc.M112332200 . free .
5. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P . Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta . Nature . 404 . 6774 . 197–201 . Mar 2000 . 10724174 . 10.1038/35004606 . 2000Natur.404..197S . 205004996 .
6. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J . Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta . The Journal of Biological Chemistry . 276 . 26 . 24153–9 . Jun 2001 . 11309393 . 10.1074/jbc.M101530200 . free .
7. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G . Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure . Nature Medicine . 9 . 12 . 1506–12 . Dec 2003 . 14608379 . 10.1038/nm958 . 20331752 .
8. Yuasa K, Michibata H, Omori K, Yanaka N . A novel interaction of cGMP-dependent protein kinase I with troponin T . The Journal of Biological Chemistry . 274 . 52 . 37429–34 . Dec 1999 . 10601315 . 10.1074/jbc.274.52.37429. free .