PRKAR1B explained

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.^{[1] [2] [3]}

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder.^[4]

Interactions

PRKAR1B has been shown to interact with AKAP1^[5] and PRKAR1A.^{[5] [6]}

Further reading

• Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L . Will diverse Tat interactions lead to novel antiretroviral drug targets? . Current Drug Targets . 7 . 12 . 1595–606 . 2007 . 17168834 . 10.2174/138945006779025338 .
• Solberg R, Taskén K, Keiserud A, Jahnsen T . Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases . Biochem. Biophys. Res. Commun. . 176 . 1 . 166–72 . 1991 . 1708242 . 10.1016/0006-291X(91)90904-L .
• Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL . HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism . J. Immunol. . 145 . 11 . 3699–705 . 1991 . 10.4049/jimmunol.145.11.3699 . 1978848 . free .
• Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL . Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes . Proc. Natl. Acad. Sci. U.S.A. . 90 . 14 . 6676–80 . 1993 . 7688126 . 46995 . 10.1073/pnas.90.14.6676 . 1993PNAS...90.6676H . free .
• Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS . Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells . Exp. Cell Res. . 214 . 2 . 595–605 . 1994 . 7925653 . 10.1006/excr.1994.1297 .
• Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL . HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro . AIDS . 8 . 7 . 1016–7 . 1994 . 7946090 . 10.1097/00002030-199407000-00025 .
• Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V . Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes . J. Biol. Chem. . 268 . 28 . 21276–83 . 1993 . 10.1016/S0021-9258(19)36921-2 . 8407966 . free .
• Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D . The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix . J. Virol. . 71 . 6 . 4372–7 . 1997 . 9151826 . 191654 . 10.1128/JVI.71.6.4372-4377.1997.
• Chen P, Mayne M, Power C, Nath A . The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases . J. Biol. Chem. . 272 . 36 . 22385–8 . 1997 . 9278385 . 10.1074/jbc.272.36.22385 . free .
• Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F . Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways . AIDS Res. Hum. Retroviruses . 14 . 10 . 825–33 . 1998 . 9671211 . 10.1089/aid.1998.14.825 .
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C . HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease . Neuroimmunomodulation . 5 . 3–4 . 184–92 . 1998 . 9730685 . 10.1159/000026336 . 19529677 .
• Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM . Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes . J. Immunol. . 162 . 9 . 5639–48 . 1999 . 10.4049/jimmunol.162.9.5639 . 10228048 . 84115936 .
• Adachi M, Lewis EJ . The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status . J. Biol. Chem. . 277 . 25 . 22915–24 . 2002 . 11943777 . 10.1074/jbc.M201695200 . free .
• Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S . Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology . Mol. Cell. Biol. . 22 . 13 . 4690–701 . 2002 . 12052877 . 133892 . 10.1128/MCB.22.13.4690-4701.2002 .
• Nguyen DT, Rovira II, Finkel T . Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A . FEBS Lett. . 521 . 1–3 . 170–4 . 2002 . 12067711 . 10.1016/S0014-5793(02)02868-5 . 2002FEBSL.521..170N . 38098581 .
• Mucignat-Caretta C, Caretta A . Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain . J. Neurocytol. . 30 . 11 . 885–94 . 2003 . 12373096 . 10.1023/A:1020613132648 . 30876154 .
• Carlson CR, Ruppelt A, Taskén K . A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system . J. Mol. Biol. . 327 . 3 . 609–18 . 2003 . 12634056 . 10.1016/S0022-2836(03)00093-7 .

Notes and References

1. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A . Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7 . Genomics . 14 . 1 . 63–9 . Dec 1992 . 1358799 . 10.1016/S0888-7543(05)80284-8 .
2. Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T . Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis . Am J Hum Genet . 41 . 5 . 925–32 . Dec 1987 . 3479018 . 1684338 .
3. Web site: Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta.
4. Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J . PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology . Brain . 137 . Pt 5 . 1361–73 . 2014 . 24722252 . 10.1093/brain/awu067 . free . 20.500.11755/abb6522f-5c5a-4833-a89e-342ac6dd3193 . free .
5. Carlson CR, Ruppelt A, Taskén K . A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system . J. Mol. Biol. . 327 . 3 . 609–18 . Mar 2003 . 12634056 . 10.1016/S0022-2836(03)00093-7 .
6. Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V . Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes . J. Biol. Chem. . 268 . 28 . 21276–83 . Oct 1993 . 10.1016/S0021-9258(19)36921-2 . 8407966 . free .