PREPL explained

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene.^{[1] [2]}

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM]

Further reading

• Martens K . PREPL: a putative novel oligopeptidase propelled into the limelight . Biol. Chem. . 387 . 7 . 879–883 . 2006 . 16913837 . 10.1515/BC.2006.111 . vanc. Derua R . Meulemans S . 3 . Waelkens . Etienne . Jaeken . Jaak . Matthijs . Gert . Creemers . John W.M. . 7983864 .
• Robertson NG . Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening . Genomics . 23 . 1 . 42–50 . 1995 . 7829101 . 10.1006/geno.1994.1457 . vanc. Khetarpal U . Gutiérrez-Espeleta GA . 3 . Bieber . FR . Morton . CC .
• Ishikawa K . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 4 . 5 . 307–313 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . vanc. Nagase T . Nakajima D . 3 . Seki . N . Ohira . M . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . free .
• Kim DK . Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells . Biochim. Biophys. Acta . 1565 . 1 . 112–122 . 2002 . 12225859 . 10.1016/S0005-2736(02)00516-3 . vanc. Kanai Y . Choi HW . 3 . Tangtrongsup . S . Chairoungdua . A . Babu . E . Tachampa . K . Anzai . N . Iribe . Y .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Parvari R . The 2p21 deletion syndrome: characterization of the transcription content . Genomics . 86 . 2 . 195–211 . 2005 . 15913950 . 10.1016/j.ygeno.2005.04.001 . vanc. Gonen Y . Alshafee I . 3 . Buriakovsky . S . Regev . K . Hershkovitz . E .
• Szeltner Z . The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity . Cell. Mol. Life Sci. . 62 . 19–20 . 2376–2381 . 2005 . 16143824 . 10.1007/s00018-005-5262-5 . vanc. Alshafee I . Juhász T . 3 . Parvari . R. . Polgár . L. . 11081394 . 11139102 .
• Jaeken J . Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome . Am. J. Hum. Genet. . 78 . 1 . 38–51 . 2006 . 16385448 . 10.1086/498852 . 1380222 . vanc. Martens K . Francois I . 3 . Eyskens . François . Lecointre . Claudine . Derua . Rita . Meulemans . Sandra . Slootstra . Jerry W. . Waelkens . Etienne .

Notes and References

1. Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E . A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease . Am J Hum Genet . 69 . 4 . 869–875 . Sep 2001 . 11524703 . 1226072 . 10.1086/323624 .
2. Web site: Entrez Gene: PREPL prolyl endopeptidase-like.