PREB explained

Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene.^{[1] [2] [3]}

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.

Further reading

• Barrios-Rodiles M . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–1625 . 2005 . 15761153 . 10.1126/science.1105776 . vanc. Brown KR . Ozdamar B . 3 . Bose . R . Liu . Z . Donovan . RS . Shinjo . F . Liu . Y . Dembowy . J . 2005Sci...307.1621B . 39457788 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Taylor Clelland CL . Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome . Mamm. Genome . 11 . 8 . 675–681 . 2000 . 10920239 . 10.1007/s003350010142 . vanc. Levy B . McKie JM . 3 . Duncan . Alessandra M.V. . Hirschhorn . Kurt . Bancroft . Carter . 22946856 .

Notes and References

1. Fliss MS, Hinkle PM, Bancroft C . Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity . Mol Endocrinol . 13 . 4 . 644–657 . May 1999 . 10194769 . 10.1210/mend.13.4.0260 . free .
2. Edgar AJ . The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12 . BMC Genomics . 4 . 18 . Jul 2003 . 1 . 12735795 . 156608 . 10.1186/1471-2164-4-18 . free .
3. Web site: Entrez Gene: PREB prolactin regulatory element binding.