PRE-084 explained

PRE-084 is a sigma receptor agonist, selective for the σ₁ subtype. It has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects.^{[1] [2] [3] [4] [5]} PRE-084 increases the expression of GDNF.^[6]

Notes and References

1. Maurice T, Su TP, Parish DW, Nabeshima T, Privat A . PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice . Pharmacology Biochemistry and Behavior . 49 . 4 . 859–69 . December 1994 . 7886099 . 10.1016/0091-3057(94)90235-6. 54306053 .
2. Maurice T . Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats . European Journal of Pharmacology . 431 . 2 . 223–7 . November 2001 . 11728429 . 10.1016/S0014-2999(01)01436-4.
3. Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL . Antitussive activity of sigma-1 receptor agonists in the guinea-pig . . 141 . 2 . 233–40 . January 2004 . 14691051 . 1574192 . 10.1038/sj.bjp.0705605 .
4. Skuza G, Rogóz Z . Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice . Pharmacological Reports . 61 . 6 . 1179–83 . 2009 . 20081254 . 10.1016/S1734-1140(09)70181-1. 96025873 .
5. Hiranita T, Soto PL, Tanda G, Katz JL . Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine . The Journal of Pharmacology and Experimental Therapeutics . 332 . 2 . 515–24 . February 2010 . 19892920 . 10.1124/jpet.109.159236 . 2812106.
6. 10.1089/neu.2010.1674 . 21332255 . 28 . 5 . Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury . May 2011 . J. Neurotrauma . 831–40 . Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X .