PRDX4 explained

Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene.^{[1] [2]} It is a member of the peroxiredoxin family of antioxidant enzymes.

Function

The protein encoded by this gene is an antioxidant enzyme of the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.

Interactions

PRDX4 has been shown to interact with Peroxiredoxin 1.

Further reading

• Sasagawa I, Matsuki S, Suzuki Y, Iuchi Y, Tohya K, Kimura M, Nakada T, Fujii J . Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats . Eur. J. Biochem. . 268 . 10 . 3053–61 . 2001 . 11358524 . 10.1046/j.1432-1327.2001.02200.x .
• Wagner E, Luche S, Penna L, Chevallet M, Van Dorsselaer A, Leize-Wagner E, Rabilloud T . A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress . Biochem. J. . 366 . Pt 3 . 777–85 . 2002 . 12059788 . 1222825 . 10.1042/BJ20020525 .
• Shen C, Nathan C . Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells . Mol. Med. . 8 . 2 . 95–102 . 2002 . 12080185 . 2039972 . 10.1007/BF03402079.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochem. Biophys. Res. Commun. . 308 . 4 . 793–801 . 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .
• Ahmed M, Forsberg J, Bergsten P . Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry . J. Proteome Res. . 4 . 3 . 931–40 . 2005 . 15952740 . 10.1021/pr050024a .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochem. Biophys. Res. Commun. . 337 . 4 . 1308–18 . 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .
• Giguère P, Turcotte ME, Hamelin E, Parent A, Brisson J, Laroche G, Labrecque P, Dupuis G, Parent JL . Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor . FEBS Lett. . 581 . 20 . 3863–8 . 2007 . 17644091 . 10.1016/j.febslet.2007.07.011 . free .

Notes and References

1. Jin DY, Chae HZ, Rhee SG, Jeang KT . Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation . J. Biol. Chem. . 272 . 49 . 30952–61 . Jan 1998 . 9388242 . 10.1074/jbc.272.49.30952 . free .
2. Web site: Entrez Gene: PRDX4 peroxiredoxin 4.