Peroxiredoxin 2 Explained

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.^{[1] [2]}

PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.^[3]

Further reading

• Yao Y, Taylor M, Davey F, RenY, Aiton J, Coote P, Chen X, Yan SD & Gunn-Moore FJ.. Interaction of Amyloid binding Alcohol Dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. . Molecular and Cellular Neuroscience . 35 . 377–82 . 2007 . 10.1016/j.mcn.2007.03.013 . 17490890 . 2 . 2415008 .
• Rasmussen HH, van Damme J, Puype M, etal . Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. . Electrophoresis . 13 . 12 . 960–9 . 1993 . 1286667 . 10.1002/elps.11501301199 . 41855774 .
• Shau H, Butterfield LH, Chiu R, Kim A . Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. . Immunogenetics . 40 . 2 . 129–34 . 1994 . 8026862 . 10.1007/BF00188176 . 7778993 .
• Chae HZ, Robison K, Poole LB, etal . Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 15 . 7017–21 . 1994 . 8041738 . 10.1073/pnas.91.15.7017 . 44329 . 1994PNAS...91.7017C . free .
• Lim YS, Cha MK, Yun CH, etal . Purification and characterization of thiol-specific antioxidant protein from human red blood cell: a new type of antioxidant protein. . Biochem. Biophys. Res. Commun. . 199 . 1 . 199–206 . 1994 . 8123012 . 10.1006/bbrc.1994.1214 .
• Lim YS, Cha MK, Kim HK, Kim IH . The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. . Gene . 140 . 2 . 279–84 . 1994 . 8144038 . 10.1016/0378-1119(94)90558-4 .
• Golaz O, Hughes GJ, Frutiger S, etal . Plasma and red blood cell protein maps: update 1993. . Electrophoresis . 14 . 11 . 1223–31 . 1994 . 8313871 . 10.1002/elps.11501401183 . 21447827 .
• Cha MK, Kim IH . Glutathione-linked thiol peroxidase activity of human serum albumin: a possible antioxidant role of serum albumin in blood plasma. . Biochem. Biophys. Res. Commun. . 222 . 2 . 619–25 . 1996 . 8670254 . 10.1006/bbrc.1996.0793 .
• Ji H, Reid GE, Moritz RL, etal . A two-dimensional gel database of human colon carcinoma proteins. . Electrophoresis . 18 . 3–4 . 605–13 . 1997 . 9150948 . 10.1002/elps.1150180344 . 25454450 .
• Wang ZM, Liu C, Dziarski R . Chemokines are the main proinflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin. . J. Biol. Chem. . 275 . 27 . 20260–7 . 2000 . 10751418 . 10.1074/jbc.M909168199 . free .
• Cha MK, Yun CH, Kim IH . Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane. . Biochemistry . 39 . 23 . 6944–50 . 2000 . 10841776 . 10.1021/bi000034j .
• Schröder E, Littlechild JA, Lebedev AA, etal . Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution. . Structure . 8 . 6 . 605–15 . 2000 . 10873855 . 10.1016/S0969-2126(00)00147-7 . free .
• Harris JR, Schröder E, Isupov MN, etal . Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography. . Biochim. Biophys. Acta . 1547 . 2 . 221–34 . 2001 . 11410278 . 10.1016/s0167-4838(01)00184-4.
• Noh DY, Ahn SJ, Lee RA, etal . Overexpression of peroxiredoxin in human breast cancer. . Anticancer Res. . 21 . 3B . 2085–90 . 2001 . 11497302 .
• Book: Kim SH, Fountoulakis M, Cairns N, Lubec G . Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down Syndrome . Protein Expression in Down Syndrome Brain . Journal of Neural Transmission. Supplementum . 61 . 223–35 . 2002 . 11771746 . 10.1007/978-3-7091-6262-0_18. 978-3-211-83704-7 .
• Rabilloud T, Heller M, Gasnier F, etal . Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. . J. Biol. Chem. . 277 . 22 . 19396–401 . 2002 . 11904290 . 10.1074/jbc.M106585200 . free .
• Anahory T, Dechaud H, Bennes R, etal . Identification of new proteins in follicular fluid of mature human follicles. . Electrophoresis . 23 . 7–8 . 1197–202 . 2002 . 11981869 . 10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2 . 24574562 .
• Shen C, Nathan C . Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. . Mol. Med. . 8 . 2 . 95–102 . 2002 . 12080185 . 10.1007/BF03402079. 2039972 .
• Geiben-Lynn R, Kursar M, Brown NV, etal . HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. . J. Biol. Chem. . 278 . 3 . 1569–74 . 2003 . 12421812 . 10.1074/jbc.M209964200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D . Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12 . Genomics . 26 . 3 . 602–6 . Aug 1995 . 7607688 . 10.1016/0888-7543(95)80183-M .
2. Web site: Entrez Gene: PRDX2 peroxiredoxin 2.
3. Web site: Entrez Gene: PRDX2 peroxiredoxin 2.