PRCC (gene) explained

Proline-rich protein PRCC is a protein that, in humans, is encoded by the PRCC gene.^{[1] [2]}

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to this gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[2]

Further reading

• Zbar B, Glenn G, Lubensky I, etal . Hereditary papillary renal cell carcinoma: clinical studies in 10 families. . J. Urol. . 153 . 3 Pt 2 . 907–12 . 1995 . 7853572 . 10.1016/S0022-5347(01)67601-8 .
• Meloni AM, Dobbs RM, Pontes JE, Sandberg AA . Translocation (X;1) in papillary renal cell carcinoma. A new cytogenetic subtype. . Cancer Genet. Cytogenet. . 65 . 1 . 1–6 . 1993 . 8431910 . 10.1016/0165-4608(93)90050-V .
• Weterman MA, Wilbrink M, Geurts van Kessel A . Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 26 . 15294–8 . 1997 . 8986805 . 10.1073/pnas.93.26.15294 . 26398 . free .
• Weterman MJ, van Groningen JJ, Jansen A, van Kessel AG . Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins. . Oncogene . 19 . 1 . 69–74 . 2000 . 10644981 . 10.1038/sj.onc.1203255 . free .
• Skalsky YM, Ajuh PM, Parker C, etal . PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors. . Oncogene . 20 . 2 . 178–87 . 2001 . 11313942 . 10.1038/sj.onc.1204056 . free .
• Weterman MA, Wilbrink M, Eleveld M, etal . Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. . Cytogenet. Cell Genet. . 92 . 3–4 . 326–32 . 2001 . 11435707 . 10.1159/000056922 . 2520925 .
• Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG . Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 24 . 13808–13 . 2002 . 11717438 . 10.1073/pnas.241304198 . 61123 . 2001PNAS...9813808W . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Anderson NL, Polanski M, Pieper R, etal . The human plasma proteome: a nonredundant list developed by combination of four separate sources. . Mol. Cell. Proteomics . 3 . 4 . 311–26 . 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS . The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene . Hum Mol Genet . 5 . 9 . 1333–8 . Jan 1997 . 8872474 . 10.1093/hmg/5.9.1333 . free .
2. Web site: Entrez Gene: PRCC papillary renal cell carcinoma (translocation-associated).