PRB3 explained

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.^{[1] [2]}

The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.

Further reading

• Book: Azen EA, Maeda N . Advances in Human Genetics 17 . Molecular Genetics of Human Salivary Proteins and Their Polymorphisms . 141–99 . 1988 . 3055850 . 10.1007/978-1-4613-0987-1_5. 978-1-4612-8279-2 .
• Azen EA, Minaguchi K, Latreille P, Kim HS . Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew. . Am. J. Hum. Genet. . 47 . 4 . 686–97 . 1990 . 2171329 . 1683781 .
• Lyons KM, Stein JH, Smithies O . Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. . Genetics . 120 . 1 . 267–78 . 1989 . 10.1093/genetics/120.1.267 . 2851479 . 1203497 .
• Maeda N, Kim HS, Azen EA, Smithies O . Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. . J. Biol. Chem. . 260 . 20 . 11123–30 . 1985 . 10.1016/S0021-9258(17)39156-1 . 2993301 . free .
• Adams MD, Kerlavage AR, Fleischmann RD, etal . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 .
• Azen E, Prakobphol A, Fisher SJ . PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. . Infect. Immun. . 61 . 10 . 4434–9 . 1993 . 8406834 . 10.1128/IAI.61.10.4434-4439.1993. 281176 .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491. 16267 . 2000PNAS...97.3491D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ . Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein . J Biol Chem . 266 . 26 . 17358–68 . Oct 1991 . 10.1016/S0021-9258(19)47381-X . 1894623 . free .
2. Web site: Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3.