PRB1 explained

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.^{[1] [2]}

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Book: Azen EA, Maeda N . Advances in Human Genetics 1 . Molecular Genetics of Human Salivary Proteins and Their Polymorphisms . 17 . 141–99 . 1988 . 3055850 . 10.1007/978-1-4613-0987-1_5. 978-1-4612-8279-2 .
• Bennick A . Salivary proline-rich proteins . Mol. Cell. Biochem. . 45 . 2 . 83–99 . 1982 . 6810092 . 10.1007/BF00223503 . 31373141 .
• Ikemoto S, Minaguchi K, Suzuki K, Tomita K . New Genetic marker in human parotid saliva (pm) . Science . 197 . 4301 . 378–9 . 1977 . 877561 . 10.1126/science.877561 . 1977Sci...197..378I .
• Castle AM, Stahl LE, Castle JD . A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum . J. Biol. Chem. . 267 . 18 . 13093–100 . 1992 . 10.1016/S0021-9258(18)42385-X . 1618808 . free .
• Lyons KM, Stein JH, Smithies O . Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over . Genetics . 120 . 1 . 267–78 . 1989 . 10.1093/genetics/120.1.267 . 2851479 . 1203497 .
• Maeda N, Kim HS, Azen EA, Smithies O . Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system . J. Biol. Chem. . 260 . 20 . 11123–30 . 1985 . 10.1016/S0021-9258(17)39156-1 . 2993301 . free .
• Kauffman D, Hofmann T, Bennick A, Keller P . Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6 . Biochemistry . 25 . 9 . 2387–92 . 1986 . 3521730 . 10.1021/bi00357a013 .
• Azen E, Lyons KM, McGonigal T, etal . Clones from the human gene complex coding for salivary proline-rich proteins . Proc. Natl. Acad. Sci. U.S.A. . 81 . 17 . 5561–5 . 1984 . 6089212 . 10.1073/pnas.81.17.5561 . 391746 . 1984PNAS...81.5561A . free .
• Saitoh E, Isemura S, Sanada K . Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H . J. Biochem. . 94 . 6 . 1991–9 . 1984 . 6671974 . 10.1093/oxfordjournals.jbchem.a134553.
• Kauffman D, Wong R, Bennick A, Keller P . Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair . Biochemistry . 21 . 25 . 6558–62 . 1983 . 6924859 . 10.1021/bi00268a036 .
• Isemura S, Saitoh E, Sanada K . Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E . J. Biochem. . 91 . 6 . 2067–75 . 1982 . 7118863 . 10.1093/oxfordjournals.jbchem.a133900.
• Kim HS, Lyons KM, Saitoh E, etal . The structure and evolution of the human salivary proline-rich protein gene family . Mamm. Genome . 4 . 1 . 3–14 . 1993 . 8422499 . 10.1007/BF00364656 . 24058984 .
• Castle AM, Castle JD . Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein . Mol. Biol. Cell . 9 . 3 . 575–83 . 1998 . 9487127 . 10.1091/mbc.9.3.575. 25286 .
• Harrington JJ, Sherf B, Rundlett S, etal . Creation of genome-wide protein expression libraries using random activation of gene expression . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 .
• Chan M, Bennick A . Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases . Eur. J. Biochem. . 268 . 12 . 3423–31 . 2001 . 11422372 . 10.1046/j.1432-1327.2001.02241.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Azen EA, Latreille P, Niece RL . PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs) . Am J Hum Genet . 53 . 1 . 264–78 . Jul 1993 . 8317492 . 1682219 .
2. Web site: Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1.