PRAM1 explained
PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.[1] [2] [3]
Function
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).
Interactions
PRAM1 has been shown to interact with TRIM27.[4]
Further reading
- Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS . PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia . Oncogene . 13 . 5 . 971–82 . 1996 . 8806687 .
- Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD . Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML . J. Cell Sci. . 111 . 10 . 1319–29 . 1998 . 10.1242/jcs.111.10.1319 . 9570750 .
- Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S . Role of PML and PML-RARalpha in Mad-mediated transcriptional repression . Mol. Cell . 7 . 6 . 1233–43 . 2001 . 11430826 . 10.1016/S1097-2765(01)00257-X . free .
- Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG . PRAM-1 potentiates arsenic trioxide-induced JNK activation . J. Biol. Chem. . 280 . 10 . 9043–8 . 2005 . 15637062 . 10.1074/jbc.M413564200 . free .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Rossi V, Levati L, Biondi A . Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR . Methods Mol. Med. . 125 . 115–26 . 2006 . 16502581 . 10.1385/1-59745-017-0:115 . 1-59745-017-0 .
- Mokany E, Todd AV, Fuery CJ, Applegate TL . Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR . Methods Mol. Med. . 125 . 127–47 . 2006 . 16502582 . 10.1385/1-59745-017-0:127 . 1-59745-017-0 .
- Heuer K, Sylvester M, Kliche S, Pusch R, Thiemke K, Schraven B, Freund C . Lipid-binding hSH3 domains in immune cell adapter proteins . J. Mol. Biol. . 361 . 1 . 94–104 . 2006 . 16831444 . 10.1016/j.jmb.2006.06.004 .
Notes and References
- Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G . PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells . J Biol Chem . 276 . 25 . 22375–81 . Jun 2001 . 11301322 . 10.1074/jbc.M011683200 . free .
- Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ . PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function . Mol Cell Biol . 24 . 24 . 10923–32 . Dec 2004 . 15572693 . 533979 . 10.1128/MCB.24.24.10923-10932.2004 .
- Web site: Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1.
- Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD . Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML . J. Cell Sci. . 111 . 10 . 1319–29 . May 1998 . 10.1242/jcs.111.10.1319 . 9570750 .
