PPRC1 explained

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.^{[1] [2] [3]}

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.

Interactions

PPRC1 has been shown to interact with USF2.^[4]

Further reading

• Finck BN, Kelly DP . PGC-1 coactivators: inducible regulators of energy metabolism in health and disease . J. Clin. Invest. . 116 . 3 . 615–22 . 2006 . 16511594 . 10.1172/JCI27794 . 1386111 .
• Yamagata K . Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner . Int. J. Mol. Med. . 19 . 5 . 751–6 . 2007 . 17390079 . 10.3892/ijmm.19.5.751. vanc. Yoshimochi K . Daitoku H . 3 . Hirota . K . Fukamizu . A . free.
• Srivastava S, Barrett JN, Moraes CT . PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations . Hum. Mol. Genet. . 16 . 8 . 993–1005 . 2007 . 17341490 . 10.1093/hmg/ddm045 . 2652746 .
• Gleyzer N, Vercauteren K, Scarpulla RC . Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators . Mol. Cell. Biol. . 25 . 4 . 1354–66 . 2005 . 15684387 . 10.1128/MCB.25.4.1354-1366.2005 . 548005 .
• Yamamoto T . SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes . J. Biol. Chem. . 279 . 13 . 12027–35 . 2004 . 14722127 . 10.1074/jbc.M310333200 . vanc. Shimano H . Nakagawa Y . 3 . Ide . T . Yahagi . N . Matsuzaka . T . Nakakuki . M . Takahashi . A . Suzuki . H . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Savagner F . PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma . Biochem. Biophys. Res. Commun. . 310 . 3 . 779–84 . 2003 . 14550271 . 10.1016/j.bbrc.2003.09.076 . vanc. Mirebeau D . Jacques C . 3 . Guyetant . Serge . Morgan . Catherine . Franc . Brigitte . Reynier . Pascal . Malthièry . Yves .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Scarpulla RC . Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells . Gene . 286 . 1 . 81–9 . 2002 . 11943463 . 10.1016/S0378-1119(01)00809-5 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
2. Andersson U, Scarpulla RC . PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells . Mol Cell Biol . 21 . 11 . 3738–49 . May 2001 . 11340167 . 87014 . 10.1128/MCB.21.11.3738-3749.2001 .
3. Web site: Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1.
4. Moore . Meredith L . Park Edwards A . McMillin Jeanie B . May 2003 . Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1 . J. Biol. Chem. . 278 . 19 . 17263–8 . United States. 0021-9258. 12611894 . 10.1074/jbc.M210486200 . free .