PPP4C explained

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.^{[1] [2]}

Interactions

PPP4C has been shown to interact with:

• CCDC6,
• CCT2,^{[3] [4]}
• CCT3,^{[3] [4]}
• CCT4,^{[3] [4]}
• CCT5,^{[3] [4]}
• CCT6A,^{[3] [4]}
• CCT7,^{[3] [4]}
• IGBP1,^{[3] [4] [5]}
• PPP2R1A,^[3]
• PPP4R1,^{[3] [4]}
• REL,^[6]
• SMEK2,^{[3] [7] [4]}
• T-complex 1,^{[3] [4]} and
• TRAF6.^[8]

Further reading

• Brewis ND, Cohen PT . Protein phosphatase X has been highly conserved during mammalian evolution . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1171 . 2 . 231–3 . Dec 1992 . 1336397 . 10.1016/0167-4781(92)90129-n .
• Brewis ND, Street AJ, Prescott AR, Cohen PT . PPX, a novel protein serine/threonine phosphatase localized to centrosomes . The EMBO Journal . 12 . 3 . 987–96 . Mar 1993 . 8384557 . 413299 . 10.1002/j.1460-2075.1993.tb05739.x.
• Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE . Carboxymethylation of nuclear protein serine/threonine phosphatase X . The Biochemical Journal . 327 (Pt 2) . Pt 2 . 481–6 . Oct 1997 . 9359419 . 1218819 . 10.1042/bj3270481.
• Chen J, Peterson RT, Schreiber SL . Alpha 4 associates with protein phosphatases 2A, 4, and 6 . Biochemical and Biophysical Research Communications . 247 . 3 . 827–32 . Jun 1998 . 9647778 . 10.1006/bbrc.1998.8792 .
• Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH . Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity . The Journal of Biological Chemistry . 273 . 50 . 33561–5 . Dec 1998 . 9837938 . 10.1074/jbc.273.50.33561 . free .
• Kloeker S, Wadzinski BE . Purification and identification of a novel subunit of protein serine/threonine phosphatase 4 . The Journal of Biological Chemistry . 274 . 9 . 5339–47 . Feb 1999 . 10026142 . 10.1074/jbc.274.9.5339 . free .
• Hastie CJ, Carnegie GK, Morrice N, Cohen PT . A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres . The Biochemical Journal . 347 Pt 3 . Pt 3 . 845–55 . May 2000 . 10769191 . 1221024 . 10.1042/0264-6021:3470845 .
• Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL . Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation . The Journal of Biological Chemistry . 279 . 25 . 26143–8 . Jun 2004 . 15073167 . 10.1074/jbc.M402362200 . free .
• Mihindukulasuriya KA, Zhou G, Qin J, Tan TH . Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation . The Journal of Biological Chemistry . 279 . 45 . 46588–94 . Nov 2004 . 15331607 . 10.1074/jbc.M408067200 . free .
• Zhou G, Boomer JS, Tan TH . Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1 . The Journal of Biological Chemistry . 279 . 47 . 49551–61 . Nov 2004 . 15364934 . 10.1074/jbc.M410317200 . free .
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E . Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4 . Genes & Development . 19 . 7 . 827–39 . Apr 2005 . 15805470 . 1074320 . 10.1101/gad.1286005 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S . Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization . Genomics . 42 . 1 . 181–2 . May 1997 . 9177794 . 10.1006/geno.1997.4693 .
2. Web site: Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit.
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 . The Journal of Biological Chemistry . 283 . 43 . 29273–84 . Oct 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Molecular & Cellular Proteomics . 4 . 11 . 1725–40 . Nov 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . free .
5. Chen J, Peterson RT, Schreiber SL . Alpha 4 associates with protein phosphatases 2A, 4, and 6 . Biochemical and Biophysical Research Communications . 247 . 3 . 827–32 . Jun 1998 . 9647778 . 10.1006/bbrc.1998.8792 .
6. Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH . Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity . The Journal of Biological Chemistry . 273 . 50 . 33561–5 . Dec 1998 . 9837938 . 10.1074/jbc.273.50.33561. free .
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 89 . 17353931 . 1847948 . 10.1038/msb4100134 . 2007 .
8. Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y . Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6 . FEBS Letters . 582 . 19 . 2843–9 . Aug 2008 . 18634786 . 10.1016/j.febslet.2008.07.014 . 27700566 . free .