PPP3R2 explained

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene.^{[1] [2]} Among its related pathways are MAPK signaling pathway^[3] and GPCR pathway.^[4] GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.^[5]

Further reading

• Mukai H, Chang CD, Tanaka H, etal . cDNA cloning of a novel testis-specific calcineurin B-like protein. . Biochem. Biophys. Res. Commun. . 179 . 3 . 1325–30 . 1991 . 1718268 . 10.1016/0006-291X(91)91718-R .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E . Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha . Virology . 303 . 1 . 174–80 . 2003 . 12482669 . 10.1006/viro.2002.1676 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Koefoed-Nielsen PB, Karamperis N, Højskov C, etal . The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients . Transpl. Int. . 19 . 10 . 821–7 . 2007 . 16961774 . 10.1111/j.1432-2277.2006.00359.x . 1891740 .
• Saeki M, Irie Y, Ni L, etal . Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation . J. Biol. Chem. . 282 . 16 . 11786–94 . 2007 . 17324936 . 10.1074/jbc.M609347200 . free .
• Jang H, Cho EJ, Youn HD . A new calcineurin inhibition domain in Cabin1 . Biochem. Biophys. Res. Commun. . 359 . 1 . 129–35 . 2007 . 17531200 . 10.1016/j.bbrc.2007.05.066 .

Notes and References

1. Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L . Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis . Mol Biol Rep . 32 . 1 . 41–5 . May 2005 . 15865209 . 10.1007/s11033-004-4250-4 . 43848098 .
2. Web site: Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform.
3. Web site: PathCards :: MAPK signaling pathway Pathway and related pathways. pathcards.genecards.org. 2015-09-08.
4. Web site: PathCards :: GPCR Pathway Pathway and related pathways. pathcards.genecards.org. 2015-09-08.
5. Web site: PPP3R2 Gene - GeneCards CANB2 Protein CANB2 Antibody. www.genecards.org. 2015-09-08. GeneCards Human Gene. Database.