PPP3CA explained

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.^[1]

Further reading

• Crabtree GR . Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT . Cell . 96 . 5 . 611–4 . March 1999 . 10089876 . 10.1016/S0092-8674(00)80571-1 . 8817053 . free .
• Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC . Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD . Science . 284 . 5412 . 339–43 . April 1999 . 10195903 . 10.1126/science.284.5412.339 . 1999Sci...284..339W .
• Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S . DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways . Human Molecular Genetics . 9 . 11 . 1681–90 . July 2000 . 10861295 . 10.1093/hmg/9.11.1681 . free .
• Frey N, Richardson JA, Olson EN . Calsarcins, a novel family of sarcomeric calcineurin-binding proteins . Proceedings of the National Academy of Sciences of the United States of America . 97 . 26 . 14632–7 . December 2000 . 11114196 . 18970 . 10.1073/pnas.260501097 . 2000PNAS...9714632F . free .
• Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y . Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism . Endocrinology . 142 . 5 . 1752–9 . May 2001 . 11316738 . 10.1210/endo.142.5.8156 . free .
• Graef IA, Chen F, Chen L, Kuo A, Crabtree GR . Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature . Cell . 105 . 7 . 863–75 . June 2001 . 11439183 . 10.1016/S0092-8674(01)00396-8 . 5278706 . free .
• Mukerjee N, McGinnis KM, Gnegy ME, Wang KK . Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation . Biochemical and Biophysical Research Communications . 285 . 5 . 1192–9 . August 2001 . 11478781 . 10.1006/bbrc.2001.5278 . 10.1.1.414.4108 .
• Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A . Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin . FEBS Letters . 503 . 2–3 . 201–5 . August 2001 . 11513882 . 10.1016/S0014-5793(01)02730-2 . 44432580 . free .
• Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J . Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells . The Journal of Experimental Medicine . 194 . 10 . 1449–59 . November 2001 . 11714752 . 2193671 . 10.1084/jem.194.10.1449 .
• Frey N, Olson EN . Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins . The Journal of Biological Chemistry . 277 . 16 . 13998–4004 . April 2002 . 11842093 . 10.1074/jbc.M200712200 . free .

Notes and References

1. Web site: Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme. 2011-12-18 .