PPP2R2C explained

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.^{[1] [2] [3]}

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

Further reading

• Zolnierowicz S . Type 2A protein phosphatase, the complex regulator of numerous signaling pathways . Biochemical Pharmacology . 60 . 8 . 1225–35 . Oct 2000 . 11007961 . 10.1016/S0006-2952(00)00424-X .
• Andersen JL, Planelles V . The role of Vpr in HIV-1 pathogenesis . Current HIV Research . 3 . 1 . 43–51 . Jan 2005 . 15638722 . 10.2174/1570162052772988 .
• Le Rouzic E, Benichou S . The Vpr protein from HIV-1: distinct roles along the viral life cycle . Retrovirology . 2 . 11 . 2006 . 15725353 . 554975 . 10.1186/1742-4690-2-11 . free .
• Zhao RY, Elder RT . Viral infections and cell cycle G2/M regulation . Cell Research . 15 . 3 . 143–9 . Mar 2005 . 15780175 . 10.1038/sj.cr.7290279 . free .
• Zhao RY, Bukrinsky M, Elder RT . HIV-1 viral protein R (Vpr) & host cellular responses . The Indian Journal of Medical Research . 121 . 4 . 270–86 . Apr 2005 . 15817944 .
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R . Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr . FEBS Letters . 401 . 2–3 . 197–201 . Jan 1997 . 9013886 . 10.1016/S0014-5793(96)01470-6 . 23293768 . free .
• Ruediger R, Brewis N, Ohst K, Walter G . Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production . Virology . 238 . 2 . 432–43 . Nov 1997 . 9400615 . 10.1006/viro.1997.8873 . free .
• Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE . Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits . The Journal of Comparative Neurology . 392 . 4 . 515–27 . Mar 1998 . 9514514 . 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3 . 20496320 .
• Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . Nov 1998 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y . HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 . Virology . 287 . 2 . 359–70 . Sep 2001 . 11531413 . 10.1006/viro.2001.1007 . free .
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER . NotI flanking sequences: a tool for gene discovery and verification of the human genome . Nucleic Acids Research . 30 . 14 . 3163–70 . Jul 2002 . 12136098 . 135748 . 10.1093/nar/gkf428 . Wasserman . Kisselev . Zabarovsky . Wahlestedt . Kashuba . Protopopov . AI . VI . C . ER . LL . W .
• Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA . Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A . The Journal of Biological Chemistry . 278 . 42 . 40829–36 . Oct 2003 . 12912990 . 10.1074/jbc.M308678200 . free .
• Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC . Identification of specific PP2A complexes involved in human cell transformation . Cancer Cell . 5 . 2 . 127–36 . Feb 2004 . 14998489 . 10.1016/S1535-6108(04)00026-1 . free .

Notes and References

1. Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH . Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit . DNA Research . 6 . 5 . 323–7 . Oct 1999 . 10574460 . 10.1093/dnares/6.5.323 . 10.1.1.575.4908 .
2. Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S . Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16 . Genomics . 67 . 1 . 83–6 . Jul 2000 . 10945473 . 10.1006/geno.2000.6219 .
3. Web site: Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform.