PPP2CB explained

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.^[1]

Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.^[2]

Interactions

PPP2CB has been shown to interact with TLX1,^[3] PPP2R1B^[4] and PPP2R1A.^{[4] [5]}

See also

• PPP2CA

Further reading

• Zolnierowicz S . Type 2A protein phosphatase, the complex regulator of numerous signaling pathways . Biochemical Pharmacology . 60 . 8 . 1225–35 . Oct 2000 . 11007961 . 10.1016/S0006-2952(00)00424-X .
• Goedert M, Cohen ES, Jakes R, Cohen P . p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] . FEBS Letters . 312 . 1 . 95–9 . Nov 1992 . 1330687 . 10.1016/0014-5793(92)81418-L . 34940651 . free .
• Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA . Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes . Biochemistry . 30 . 1 . 89–97 . Jan 1991 . 1846293 . 10.1021/bi00215a014 .
• Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM . Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A . Cell . 60 . 1 . 167–76 . Jan 1990 . 2153055 . 10.1016/0092-8674(90)90726-U . 2007706 .
• Virshup DM, Kauffman MG, Kelly TJ . Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A . The EMBO Journal . 8 . 12 . 3891–8 . Dec 1989 . 2555176 . 402079 . 10.1002/j.1460-2075.1989.tb08568.x.
• Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL . Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes . Proceedings of the National Academy of Sciences of the United States of America . 85 . 12 . 4252–6 . Jun 1988 . 2837763 . 280405 . 10.1073/pnas.85.12.4252 . 1988PNAS...85.4252A . free .
• Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR . The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit . Nucleic Acids Research . 16 . 23 . 11366 . Dec 1988 . 2849765 . 339017 . 10.1093/nar/16.23.11366 .
• Favre B, Zolnierowicz S, Turowski P, Hemmings BA . The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo . The Journal of Biological Chemistry . 269 . 23 . 16311–7 . Jun 1994 . 10.1016/S0021-9258(17)34009-7 . 8206937 . free .
• Keranen LM, Dutil EM, Newton AC . Protein kinase C is regulated in vivo by three functionally distinct phosphorylations . Current Biology . 5 . 12 . 1394–1403 . Dec 1995 . 8749392 . 10.1016/S0960-9822(95)00277-6 . 15610228 . free . 1995CBio....5.1394K .
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R . Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr . FEBS Letters . 401 . 2–3 . 197–201 . Jan 1997 . 9013886 . 10.1016/S0014-5793(96)01470-6 . 23293768 . free .
• Nagase T, Murakami T, Nozaki H, Inoue R, Nishito Y, Tanabe O, Usui H, Takeda M . Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit . Journal of Biochemistry . 122 . 1 . 178–87 . Jul 1997 . 9276686 . 10.1093/oxfordjournals.jbchem.a021726 .
• Ruediger R, Brewis N, Ohst K, Walter G . Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production . Virology . 238 . 2 . 432–43 . Nov 1997 . 9400615 . 10.1006/viro.1997.8873 . free .
• Hsu W, Zeng L, Costantini F . Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain . The Journal of Biological Chemistry . 274 . 6 . 3439–45 . Feb 1999 . 9920888 . 10.1074/jbc.274.6.3439 . free .
• Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC . A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A . The Journal of Biological Chemistry . 274 . 20 . 14382–91 . May 1999 . 10318862 . 3503312 . 10.1074/jbc.274.20.14382 . free .
• De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J . Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue . Biochemistry . 38 . 50 . 16539–47 . Dec 1999 . 10600115 . 10.1021/bi991646a .
• Götz J, Probst A, Mistl C, Nitsch RM, Ehler E . Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development . Mechanisms of Development . 93 . 1–2 . 83–93 . May 2000 . 10781942 . 10.1016/S0925-4773(00)00267-7 . 496289 . free .
• Lüss H, Klein-Wiele O, Bokník P, Herzig S, Knapp J, Linck B, Müller FU, Scheld HH, Schmid C, Schmitz W, Neumann J . Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart . Journal of Molecular and Cellular Cardiology . 32 . 12 . 2349–59 . Dec 2000 . 11113010 . 10.1006/jmcc.2000.1265 .

Notes and References

1. Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT . Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively . Cytogenetics and Cell Genetics . 63 . 1 . 35–41 . April 1993 . 8383590 . 10.1159/000133497 .
2. Web site: Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform.
3. Kawabe T, Muslin AJ, Korsmeyer SJ . HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint . Nature . 385 . 6615 . 454–8 . Jan 1997 . 9009195 . 10.1038/385454a0 . 1997Natur.385..454K . 608633 .
4. Zhou J, Pham HT, Ruediger R, Walter G . Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution . The Biochemical Journal . 369 . Pt 2 . 387–98 . Jan 2003 . 12370081 . 1223084 . 10.1042/BJ20021244 .
5. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Molecular & Cellular Proteomics . 8 . 1 . 157–71 . Jan 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .