PPP1R13L explained

RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene.^{[1] [2]}

Interactions

PPP1R13L has been shown to interact with Sp1 transcription factor^[3] and RELA.^[3]

Further reading

• Liu ZJ, Lu X, Zhong S . ASPP--Apoptotic specific regulator of p53 . Biochimica et Biophysica Acta (BBA) - Reviews on Cancer . 1756 . 1 . 77–80 . September 2005 . 16139958 . 10.1016/j.bbcan.2005.08.002 .
• Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T . RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions . Journal of Virology . 76 . 16 . 8019–30 . August 2002 . 12134007 . 155123 . 10.1128/JVI.76.16.8019-8030.2002 .
• Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X . iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human . Nature Genetics . 33 . 2 . 162–7 . February 2003 . 12524540 . 10.1038/ng1070 . 22841392 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, Jin B, Trigiante G, Lu X . The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization . Oncogene . 23 . 56 . 9007–16 . December 2004 . 15489900 . 10.1038/sj.onc.1208088 . free .
• Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G . Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors . Nature Medicine . 10 . 12 . 1321–8 . December 2004 . 15558054 . 10.1038/nm1146 . 82043 .
• Zhang X, Wang M, Zhou C, Chen S, Wang J . The expression of iASPP in acute leukemias . Leukemia Research . 29 . 2 . 179–83 . February 2005 . 15607367 . 10.1016/j.leukres.2004.07.001 .
• Laska MJ, Nexø BA, Vistisen K, Poulsen HE, Loft S, Vogel U . Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer . Cancer Letters . 225 . 2 . 245–51 . July 2005 . 15885892 . 10.1016/j.canlet.2005.03.021 .
• Skjelbred CF, Saebø M, Nexø BA, Wallin H, Hansteen IL, Vogel U, Kure EH . Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study . BMC Cancer . 6 . 175 . July 2006 . 16817948 . 1533843 . 10.1186/1471-2407-6-175 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X . iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53 . Nature Genetics . 38 . 10 . 1133–41 . October 2006 . 16964264 . 10.1038/ng1879 . 27662568 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Zhang X, Diao S, Rao Q, Xing H, Liu H, Liao X, Wang M, Wang J . Identification of a novel isoform of iASPP and its interaction with p53 . Journal of Molecular Biology . 368 . 4 . 1162–71 . May 2007 . 17391696 . 10.1016/j.jmb.2007.03.001 .
• Laska MJ, Strandbygård D, Kjeldgaard A, Mains M, Corydon TJ, Memon AA, Sørensen BS, Vogel U, Jensen UB, Nexø BA . Expression of the RAI gene is conducive to apoptosis: studies of induction and interference . Experimental Cell Research . 313 . 12 . 2611–21 . July 2007 . 17570360 . 10.1016/j.yexcr.2007.05.006 .

Notes and References

1. Yang JP, Hori M, Sanda T, Okamoto T . Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor . The Journal of Biological Chemistry . 274 . 22 . 15662–70 . May 1999 . 10336463 . 10.1074/jbc.274.22.15662 . free .
2. Web site: Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like.
3. Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T . RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions . Journal of Virology . 76 . 16 . 8019–30 . August 2002 . 12134007 . 155123 . 10.1128/JVI.76.16.8019-8030.2002 .