PPP1R11 explained

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.^{[1] [2] [3]}

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.

The gene is located within the major histocompatibility complex class I region on chromosome 6.

Further reading

• Amadou C, Ribouchon MT, Mattei MG, etal . Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes . Genomics . 26 . 1 . 9–20 . 1995 . 7782091 . 10.1016/0888-7543(95)80077-Y .
• el Kahloun A, Chauvel B, Mauvieux V, etal . Localization of seven new genes around the HLA-A locus . Hum. Mol. Genet. . 2 . 1 . 55–60 . 1993 . 8490624 . 10.1093/hmg/2.1.55 .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Lepourcelet M, Andrieux N, Giffon T, etal . Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence . Genomics . 37 . 3 . 316–26 . 1997 . 8938444 . 10.1006/geno.1996.0566 .
• Yu W, Andersson B, Worley KC, etal . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Lesage B, Beullens M, Pedelini L, etal . A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3 . Biochemistry . 46 . 31 . 8909–19 . 2007 . 17630778 . 10.1021/bi7003119 .

Notes and References

1. Ernest Y. C. Lee . Zhang J, Zhang L, Zhao S, Lee EY . Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1 . Biochemistry . 37 . 47 . 16728–34 . Dec 1998 . 9843442 . 10.1021/bi981169g .
2. Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V . Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region . Immunogenetics . 44 . 5 . 331–9 . Oct 1996 . 8781118 . 10.1007/BF02602777 . 7130465 .
3. Web site: Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11.