Protein phosphatase methylesterase-1 explained

Protein phosphatase methylesterase-1
Ec Number:	3.1.1.89

The enzyme protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1; systematic name (phosphatase 2A protein)-leucine ester acylhydrolase^{[1] [2]} catalyses the reaction

[phosphatase 2A protein]-leucine methyl ester + H₂O

\rightleftharpoons [phosphatase 2A protein]-leucine + methanol

A key regulator of protein phosphatase 2A.

Notes and References

1. Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC . A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A . The Journal of Biological Chemistry . 274 . 20 . 14382–91 . May 1999 . 10318862 . 3503312 . 10.1074/jbc.274.20.14382 . free .
2. Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y . Structural mechanism of demethylation and inactivation of protein phosphatase 2A . Cell . 133 . 1 . 154–63 . April 2008 . 18394995 . 10.1016/j.cell.2008.02.041 . free .