PPIP5K2 explained

Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.^[1]

Function

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• John R. Falck . Wang H, Falck JR, Hall TM, Shears SB . Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding . Nat. Chem. Biol. . 8 . 1 . 111–6 . 2011 . 22119861 . 3923263 . 10.1038/nchembio.733 .
• Weaver JD, Wang H, Shears SB . The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment . Biosci. Rep. . 33 . 2 . e00022 . 2013 . 23240582 . 3564036 . 10.1042/BSR20120115 .
• Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB . Identification of a functional nuclear translocation sequence in hPPIP5K2 . BMC Cell Biol. . 16 . 17 . 2015 . 26084399 . 4472268 . 10.1186/s12860-015-0063-7 . free .

Notes and References

1. Web site: Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2. 2017-03-21.