PPIL3 explained

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.^{[1] [2]}

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.

Further reading

• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . Apr 2002 . 11991638 . 1370266 . 10.1017/S1355838202021088 .
• Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX . Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family . Acta Crystallographica Section D . 61 . Pt 3 . 316–21 . Mar 2005 . 15735342 . 10.1107/S0907444904033189 .
• Qi ZY, Hui GZ, Li Y, Zhou ZX, Gu SH, Ying K, Xie Y . cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene . Chinese Medical Journal . 118 . 10 . 799–805 . May 2005 . 15989758 .
• Hu H, Huang CQ, Liu HL, Han Y, Yu L, Bi RC . Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J . Acta Crystallographica Section F . 61 . Pt 2 . 216–8 . Feb 2005 . 16510998 . 1952245 . 10.1107/S1744309105000643 .

Notes and References

1. Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y . Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain . Cytogenetics and Cell Genetics . 92 . 3–4 . 231–6 . Jul 2001 . 11435694 . 10.1159/000056909 . 713529 .
2. Web site: Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3.