PPIL1 explained

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.^{[1] [2] [3]}

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.

Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Further reading

• Tripodis N, Mason R, Humphray SJ, etal . Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. . Genome Res. . 8 . 6 . 631–43 . 1999 . 9647638 . 10.1101/gr.8.6.631. 310739 .
• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .
• Jurica MS, Licklider LJ, Gygi SR, etal . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Xu C, Xu Y, Tang Y, etal . Backbone and side chain assignments of human Peptidylprolyl Isomerase Like 1 (hPPIL1). . J. Biomol. NMR . 31 . 2 . 179–80 . 2005 . 15772761 . 10.1007/s10858-004-8238-0 . 30456850 .
• Xu C, Zhang J, Huang X, etal . Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. . J. Biol. Chem. . 281 . 23 . 15900–8 . 2006 . 16595688 . 10.1074/jbc.M511155200 . free .

Notes and References

1. Mann SS, Pettenati MJ, von Kap-herr C, Hart TC . Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization . Cytogenet Cell Genet . 83 . 3–4 . 228–9 . Mar 1999 . 10072585 . 10.1159/000015186 . 85413695 .
2. Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S . Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain . Cytogenet Cell Genet . 72 . 2–3 . 242–5 . Jan 1997 . 8978786 . 10.1159/000134199 .
3. Web site: Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1.