PPIH explained

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.

Further reading

• Reidt U . Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin . J. Biol. Chem. . 275 . 11 . 7439–42 . 2000 . 10713041 . 10.1074/jbc.275.11.7439 . vanc. Reuter K . Achsel T . 3 . Ingelfinger . D . Lührmann . R . Ficner . R . 20261807 . free.
• Horowitz DS, Lee EJ, Mabon SA, Misteli T . A cyclophilin functions in pre-mRNA splicing . EMBO J. . 21 . 3 . 470–80 . 2002 . 11823439 . 10.1093/emboj/21.3.470 . 125845 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Reidt U . Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide . J. Mol. Biol. . 331 . 1 . 45–56 . 2003 . 12875835 . 10.1016/S0022-2836(03)00684-3 . vanc. Wahl MC . Fasshauer D . 3 . Horowitz . David S. . Lührmann . Reinhard . Ficner . Ralf . 11858/00-001M-0000-0012-F238-B . free.
• Ingelfinger D . Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH . Nucleic Acids Res. . 31 . 16 . 4791–6 . 2004 . 12907720 . 10.1093/nar/gkg660 . 169899 . vanc. Göthel SF . Marahiel MA . 3 . Reidt . U . Ficner . R . Lührmann . R . Achsel . T .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Horowitz DS, Kobayashi R, Krainer AR . A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs . RNA . 3 . 12 . 1374–87 . Dec 1997 . 9404889 . 1369579 .
2. Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R . The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins . RNA . 4 . 2 . 127–41 . May 1998 . 9570313 . 1369602 .
3. Web site: Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H).