PPARGC1B explained

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.^{[1] [2] [3]}

See also

• PPARGC1A
• Peroxisome proliferator-activated receptor
• Peroxisome proliferator-activated receptor alpha
• Peroxisome proliferator-activated receptor delta
• Peroxisome proliferator-activated receptor gamma
• Transcription coregulator

Further reading

• Handschin C, Spiegelman BM . Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. . Endocr. Rev. . 27 . 7 . 728–35 . 2007 . 17018837 . 10.1210/er.2006-0037 . free .
• Esterbauer H, Oberkofler H, Krempler F, Patsch W . Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. . Genomics . 62 . 1 . 98–102 . 2000 . 10585775 . 10.1006/geno.1999.5977 .
• Knutti D, Kaul A, Kralli A . A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. . Mol. Cell. Biol. . 20 . 7 . 2411–22 . 2000 . 10713165 . 10.1128/MCB.20.7.2411-2422.2000 . 85422 .
• Lin J, Puigserver P, Donovan J, etal . Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. . J. Biol. Chem. . 277 . 3 . 1645–8 . 2002 . 11733490 . 10.1074/jbc.C100631200 . free .
• Lacquemant C, Chikri M, Boutin P, etal . No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. . Diabetologia . 45 . 4 . 602–3; author reply 604 . 2002 . 12032643 . 10.1007/s00125-002-0783-z .
• Hara K, Tobe K, Okada T, etal . A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. . Diabetologia . 45 . 5 . 740–3 . 2003 . 12107756 . 10.1007/s00125-002-0803-z . free .
• Huss JM, Kopp RP, Kelly DP . Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. . J. Biol. Chem. . 277 . 43 . 40265–74 . 2002 . 12181319 . 10.1074/jbc.M206324200 . free .
• Hentschke M, Süsens U, Borgmeyer U . PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. . Biochem. Biophys. Res. Commun. . 299 . 5 . 872–9 . 2003 . 12470660 . 10.1016/S0006-291X(02)02753-5 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shiraki T, Sakai N, Kanaya E, Jingami H . Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. . J. Biol. Chem. . 278 . 13 . 11344–50 . 2003 . 12551939 . 10.1074/jbc.M212859200 . free .
• Hammarstedt A, Jansson PA, Wesslau C, etal . Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. . Biochem. Biophys. Res. Commun. . 301 . 2 . 578–82 . 2003 . 12565902 . 10.1016/S0006-291X(03)00014-7 .
• Meirhaeghe A, Crowley V, Lenaghan C, etal . Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. . Biochem. J. . 373 . Pt 1 . 155–65 . 2003 . 12678921 . 10.1042/BJ20030200 . 1223480 .
• Patti ME, Butte AJ, Crunkhorn S, etal . Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 14 . 8466–71 . 2003 . 12832613 . 10.1073/pnas.1032913100 . 166252 . 2003PNAS..100.8466P . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Ling C, Poulsen P, Carlsson E, etal . Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. . J. Clin. Invest. . 114 . 10 . 1518–26 . 2004 . 15546003 . 10.1172/JCI21889 . 525741 .
• Andersen G, Wegner L, Yanagisawa K, etal . Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. . J. Med. Genet. . 42 . 5 . 402–7 . 2006 . 15863669 . 10.1136/jmg.2004.026278 . 1736055 .
• Staiger H, Staiger K, Haas C, etal . Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. . Diabetologia . 48 . 10 . 2115–8 . 2005 . 16132959 . 10.1007/s00125-005-1895-z . free .
• Wirtenberger M, Tchatchou S, Hemminki K, etal . Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. . Carcinogenesis . 27 . 11 . 2201–8 . 2006 . 16704985 . 10.1093/carcin/bgl067 . free .

Notes and References

1. Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O . Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus . Diabetologia . 44 . 12 . 2220–6 . Jan 2002 . 11793024 . 10.1007/s001250100032 . free .
2. Kressler D, Schreiber SN, Knutti D, Kralli A . The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha . J Biol Chem . 277 . 16 . 13918–25 . Apr 2002 . 11854298 . 10.1074/jbc.M201134200 . free .
3. Web site: Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta.