Phosphatidic acid phosphatase 2c explained

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[4]

Further reading

• Nanjundan M, Possmayer F . Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. . Am. J. Physiol. Lung Cell Mol. Physiol. . 284 . 1 . L1–23 . 2003 . 12471011 . 10.1152/ajplung.00029.2002 .
• Morris KE, Schang LM, Brindley DN . Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. . J. Biol. Chem. . 281 . 14 . 9297–306 . 2006 . 16467304 . 10.1074/jbc.M511710200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Zhang N, Sundberg JP, Gridley T . Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. . Genesis . 27 . 4 . 137–40 . 2000 . 10992322 . 10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4 . 24643785 .
• Roberts R, Sciorra VA, Morris AJ . Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. . J. Biol. Chem. . 273 . 34 . 22059–67 . 1998 . 9705349 . 10.1074/jbc.273.34.22059 . free .

Notes and References

1. Leung DW, Tompkins CK, White T . Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells . DNA Cell Biol . 17 . 4 . 377–85 . May 1998 . 9570154 . 10.1089/dna.1998.17.377 .
2. Hooks SB, Ragan SP, Lynch KR . Identification of a novel human phosphatidic acid phosphatase type 2 isoform . FEBS Lett . 427 . 2 . 188–92 . Jun 1998 . 9607309 . 10.1016/S0014-5793(98)00421-9 . 31610109 .
3. Web site: Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C.
4. Web site: Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C.