POU4F3 explained

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.^{[1] [2]} It's a member of BRN-3 group, also known as POU family class 4.

Nomenclature

DFNA15 refers to a type of nonsyndromic deafness, with autosomal dominant inheritance.

Further reading

In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

• 2017. Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.. Gene. 400. 1–2. 89–97. 10.1016/j.gene.2007.05.023. 17611044. Nolan LS, Jagutpal SS, Cadge BA, etal.
• 2004. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res.. 14. 10B. 2121–7. 10.1101/gr.2596504. 528928. 15489334. Gerhard DS, Wagner L, Feingold EA, etal.
• 2004. Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem. Biophys. Res. Commun.. 324. 1. 372–81. 10.1016/j.bbrc.2004.09.074. 15465029. Clough RL, Sud R, Davis-Silberman N, etal.
• 2003. The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity. Mol. Cell. Biol.. 23. 22. 7957–64. 10.1128/MCB.23.22.7957-7964.2003. 262385. 14585957. Weiss S, Gottfried I, Mayrose I, etal.
• 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A.. 99. 26. 16899–903. 10.1073/pnas.242603899. 139241. 12477932. Strausberg RL, Feingold EA, Grouse LH, etal. 2002PNAS...9916899M . free.
• 2002. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int. J. Cancer. 101. 2. 103–10. 10.1002/ijc.10554. 12209986. Leonard JH, Cook AL, Van Gele M, etal. 20592545.
• 1996. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 381. 6583. 603–6. 10.1038/381603a0. 8637595. Erkman L, McEvilly RJ, Luo L, etal. 1996Natur.381..603E . 37343529.
• 1995. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosci.. 15. 7 Pt 1. 4762–85. 10.1523/JNEUROSCI.15-07-04762.1995. 7623109. 6577904. Xiang M, Zhou L, Macke JP, etal.

Notes and References

1. Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB . Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans . Science . 279 . 5358 . 1950–4 . Apr 1998 . 9506947 . 10.1126/science.279.5358.1950 . 25291858 . free . 1998Sci...279.1950V .
2. Web site: Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3.