POLR3F explained
DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.[1] [2]
Function
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.[2]
Further reading
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
- Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N . Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits . Molecular and Cellular Biology . 22 . 22 . 8044–55 . Nov 2002 . 12391170 . 134740 . 10.1128/MCB.22.22.8044-8055.2002 .
- Jones E, Kimura H, Vigneron M, Wang Z, Roeder RG, Cook PR . Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III . Experimental Cell Research . 254 . 1 . 163–72 . Jan 2000 . 10623476 . 10.1006/excr.1999.4739 .
- Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG . The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity . Molecular and Cellular Biology . 19 . 11 . 7697–704 . Nov 1999 . 10523658 . 84812 . 10.1128/mcb.19.11.7697.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Jang KL, Collins MK, Latchman DS . The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC . Journal of Acquired Immune Deficiency Syndromes . 5 . 11 . 1142–7 . 1992 . 1403646 .
Notes and References
- Wang Z, Roeder RG . Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation . Genes & Development . 11 . 10 . 1315–26 . May 1997 . 9171375 . 10.1101/gad.11.10.1315 . free .
- Web site: Entrez Gene: POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa.
