POLR3D explained

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.^{[1] [2] [3]}

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.^[4]

Interactions

POLR3D has been shown to interact with POLR3E.

Further reading

• Jang KL, Collins MK, Latchman DS . The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. . J. Acquir. Immune Defic. Syndr. . 5 . 11 . 1142–7 . 1992 . 1403646 .
• Greco A, Ittmann M, Barletta C, etal . Chromosomal localization of human genes required for G1 progression in mammalian cells. . Genomics . 4 . 3 . 240–5 . 1989 . 2714790 . 10.1016/0888-7543(89)90326-1 .
• Ittmann M, Greco A, Basilico C . Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells. . Mol. Cell. Biol. . 7 . 10 . 3386–93 . 1988 . 3683386 . 10.1128/MCB.7.10.3386. 367988 .
• Jackson AJ, Ittmann M, Pugh BF . The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing. . Mol. Cell. Biol. . 15 . 1 . 94–101 . 1995 . 7799973 . 10.1128/MCB.15.1.94. 231913 .
• Ittmann MM . Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III. . Cell Growth Differ. . 5 . 7 . 783–8 . 1994 . 7947392 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N . Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits . Mol Cell Biol . 22 . 22 . 8044–55 . Oct 2002 . 12391170 . 134740 . 10.1128/MCB.22.22.8044-8055.2002 .
2. Chong SS, Hu P, Hernandez N . Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex . J Biol Chem . 276 . 23 . 20727–34 . Jun 2001 . 11279001 . 10.1074/jbc.M100088200 . free .
3. Web site: Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa.
4. Web site: Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa.