POLR3C explained

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.^{[1] [2] [3]}

Interactions

POLR3C has been shown to interact with GTF3C4.^{[4] [5]}

Related gene problems

• TAR syndrome^[6]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

Further reading

• Jang KL, Collins MK, Latchman DS . The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC . Journal of Acquired Immune Deficiency Syndromes . 5 . 11 . 1142–7 . 1992 . 1403646 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG . Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III . Molecular and Cellular Biology . 19 . 7 . 4944–52 . July 1999 . 10373544 . 84305 . 10.1128/mcb.19.7.4944 .
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG . The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity . Molecular and Cellular Biology . 19 . 11 . 7697–704 . November 1999 . 10523658 . 84812 . 10.1128/mcb.19.11.7697 .
• Kuwana M, Kimura K, Kawakami Y . Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay . Arthritis and Rheumatism . 46 . 10 . 2742–7 . October 2002 . 12384934 . 10.1002/art.10521 . free .

Notes and References

1. Wang Z, Roeder RG . Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation . Genes & Development . 11 . 10 . 1315–26 . May 1997 . 9171375 . 10.1101/gad.11.10.1315 . free .
2. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N . Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits . Molecular and Cellular Biology . 22 . 22 . 8044–55 . November 2002 . 12391170 . 134740 . 10.1128/MCB.22.22.8044-8055.2002 .
3. Web site: Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD).
4. Hsieh YJ, Wang Z, Kovelman R, Roeder RG . Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III . Molecular and Cellular Biology . 19 . 7 . 4944–52 . July 1999 . 10373544 . 84305 . 10.1128/mcb.19.7.4944 .
5. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG . The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity . Molecular and Cellular Biology . 19 . 11 . 7697–704 . November 1999 . 10523658 . 84812 . 10.1128/mcb.19.11.7697 .
6. Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S . 6 . Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome . American Journal of Human Genetics . 80 . 2 . 232–40 . February 2007 . 17236129 . 1785342 . 10.1086/510919 .