POLR2J2 explained

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.^[1]

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.

Further reading

• Shpakovskii DG, Shematorova EK, Shpakovskii GV . Human PMS2 gene family: origin, molecular evolution, and biological implications . Dokl. Biochem. Biophys. . 408 . 175–179 . 2006 . 16913423 . 10.1134/S1607672906030185 . 30897463 .
• Benga WJ . Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II . Nucleic Acids Res. . 33 . 11 . 3582–3590 . 2005 . 15987790 . 10.1093/nar/gki672 . 1159119 . vanc. Grandemange S . Shpakovski GV . 3 . Shematorova . EK . Kedinger . C . Vigneron . M .
• Shpakovskiĭ DG, Shematorova EK, Shpakovskiĭ GV . [New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family] . Bioorg. Khim. . 30 . 6 . 621–5 . 2005 . 15586814 . 10.1023/b:rubi.0000049773.14555.4c. 1452697 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Durrin LK, Krontiris TG . The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11 . Genomics . 79 . 6 . 809–817 . 2002 . 12036295 . 10.1006/geno.2002.6772 .
• Grandemange S . A human RNA polymerase II subunit is encoded by a recently generated multigene family . BMC Mol. Biol. . 2. 14 . 2003 . 11747469 . 10.1186/1471-2199-2-14 . 61041 . vanc. Schaller S . Yamano S . 3 . Du Manoir . Stanislas . Shpakovski . George V . Mattei . Marie-Geneviève . Kedinger . Claude . Vigneron . Marc . free .
• Cramer P . Architecture of RNA polymerase II and implications for the transcription mechanism . Science . 288 . 5466 . 640–649 . 2000 . 10784442 . 10.1126/science.288.5466.640 . vanc. Bushnell DA . Fu J . 3 . Gnatt . AL . Maier-Davis . B . Thompson . NE . Burgess . RR . Edwards . AM . David . PR . 2000Sci...288..640C . 11858/00-001M-0000-0015-872F-3 . free .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .

Notes and References

1. Web site: Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene.