POLR1E explained

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.^{[1] [2]}

Interactions

POLR1E has been shown to interact with CD3EAP^[3] and POLR1C.^{[4] [3] [5]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Seither P, Zatsepina O, Hoffmann M, Grummt I . Constitutive and strong association of PAF53 with RNA polymerase I . Chromosoma . 106 . 4 . 216–25 . Sep 1997 . 9254723 . 10.1007/s004120050242 . 23487728 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Voit R, Grummt I . Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription . Proceedings of the National Academy of Sciences of the United States of America . 98 . 24 . 13631–6 . Nov 2001 . 11698641 . 61092 . 10.1073/pnas.231071698 . 2001PNAS...9813631V . free .
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ . Functional proteomic analysis of human nucleolus . Molecular Biology of the Cell . 13 . 11 . 4100–9 . Nov 2002 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 .
• Bjerregaard B, Wrenzycki C, Strejcek F, Laurincik J, Holm P, Ochs RL, Rosenkranz C, Callesen H, Rath D, Niemann H, Maddox-Hyttel P . Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro . Biology of Reproduction . 70 . 4 . 867–76 . Apr 2004 . 14585813 . 10.1095/biolreprod.103.021683 . free .
• Baran V, Pavlok A, Bjerregaard B, Wrenzycki C, Hermann D, Philimonenko VV, Lapathitis G, Hozak P, Niemann H, Motlik J . Immunolocalization of upstream binding factor and pocket protein p130 during final stages of bovine oocyte growth . Biology of Reproduction . 70 . 4 . 877–86 . Apr 2004 . 14613906 . 10.1095/biolreprod.103.018408 . 43563796 .
• Bjerregaard B, Wrenzycki C, Philimonenko VV, Hozak P, Laurincik J, Niemann H, Motlik J, Maddox-Hyttel P . Regulation of ribosomal RNA synthesis during the final phases of porcine oocyte growth . Biology of Reproduction . 70 . 4 . 925–35 . Apr 2004 . 14627545 . 10.1095/biolreprod.103.020941 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . Feb 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M . Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription . Molecular and Cellular Biology . 24 . 14 . 6338–49 . Jul 2004 . 15226435 . 434256 . 10.1128/MCB.24.14.6338-6349.2004 .
• Percipalle P, Fomproix N, Cavellán E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Farrants AK . The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription . EMBO Reports . 7 . 5 . 525–30 . May 2006 . 16514417 . 1479564 . 10.1038/sj.embor.7400657 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, Muramatsu M . RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription . The EMBO Journal . 15 . 9 . 2217–26 . May 1996 . 8641287 . 450146 . 10.1002/j.1460-2075.1996.tb00575.x.
2. Web site: Entrez Gene: POLR1E polymerase (RNA) I polypeptide E, 53kDa.
3. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M . Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription . Molecular and Cellular Biology . 24 . 14 . 6338–49 . Jul 2004 . 15226435 . 434256 . 10.1128/MCB.24.14.6338-6349.2004 .
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
5. Seither P, Zatsepina O, Hoffmann M, Grummt I . Constitutive and strong association of PAF53 with RNA polymerase I . Chromosoma . 106 . 4 . 216–25 . Sep 1997 . 9254723 . 10.1007/s004120050242 . 23487728 .