POLR1B explained

DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene.^[1]

Further reading

• Seither P, Zatsepina O, Hoffmann M, Grummt I . Constitutive and strong association of PAF53 with RNA polymerase I. . Chromosoma . 106 . 4 . 216–25 . 1997 . 9254723 . 10.1007/s004120050242 . 23487728 .
• Miller G, Panov KI, Friedrich JK . hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters . EMBO J. . 20 . 6 . 1373–82 . 2001 . 11250903 . 10.1093/emboj/20.6.1373 . 145519 .
• Seither P, Iben S, Thiry M, Grummt I . PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I . Biol. Chem. . 382 . 8 . 1163–70 . 2002 . 11592397 . 10.1515/BC.2001.146 . 28819190 .
• Shiau AK, Barstad D, Radek JT . Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism . Nat. Struct. Biol. . 9 . 5 . 359–64 . 2002 . 11953755 . 10.1038/nsb787 . 452305 .
• Egea PF, Mitschler A, Moras D . Molecular recognition of agonist ligands by RXRs . Mol. Endocrinol. . 16 . 5 . 987–97 . 2002 . 11981034 . 10.1210/mend.16.5.0823 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Yamamoto K, Yamamoto M, Hanada K . Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription . Mol. Cell. Biol. . 24 . 14 . 6338–49 . 2004 . 15226435 . 10.1128/MCB.24.14.6338-6349.2004 . 434256 .
• Philimonenko VV, Zhao J, Iben S . Nuclear actin and myosin I are required for RNA polymerase I transcription . Nat. Cell Biol. . 6 . 12 . 1165–72 . 2005 . 15558034 . 10.1038/ncb1190 . 6633625 .
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Zhang C, Comai L, Johnson DL . PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex . Mol. Cell. Biol. . 25 . 16 . 6899–911 . 2005 . 16055704 . 10.1128/MCB.25.16.6899-6911.2005 . 1190253 .
• Percipalle P, Fomproix N, Cavellán E . The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription . EMBO Rep. . 7 . 5 . 525–30 . 2006. 16514417 . 10.1038/sj.embor.7400657 . 1479564 .
• Panova TB, Panov KI, Russell J, Zomerdijk JC . Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription . Mol. Cell. Biol. . 26 . 16 . 5957–68 . 2006 . 16880508 . 10.1128/MCB.00673-06 . 1592790 .
• Johnson SS, Zhang C, Fromm J . Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases . Mol. Cell . 26 . 3 . 367–79 . 2007 . 17499043 . 10.1016/j.molcel.2007.03.021 . free .

Notes and References

1. Web site: Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa.