POLR1A explained

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.^{[1] [2]}

Further reading

• Zhu L, Perlaky L, Henning D, Valdez BC . Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family. . Biochem. Mol. Biol. Int. . 42 . 5 . 927–35 . 1998 . 9285060 . 10.1080/15216549700203371. 19749385 . free .
• Chen HK, Pai CY, Huang JY, Yeh NH . Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. . Mol. Cell. Biol. . 19 . 12 . 8536–46 . 2000 . 10567578 . 10.1128/mcb.19.12.8536. 84972 .
• Miller G, Panov KI, Friedrich JK, etal . hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. . EMBO J. . 20 . 6 . 1373–82 . 2001 . 11250903 . 10.1093/emboj/20.6.1373 . 145519 .
• Yuan X, Zhao J, Zentgraf H, etal . Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. . EMBO Rep. . 3 . 11 . 1082–7 . 2003 . 12393749 . 10.1093/embo-reports/kvf212 . 1307603 .
• Dundr M, Hoffmann-Rohrer U, Hu Q, etal . A kinetic framework for a mammalian RNA polymerase in vivo. . Science . 298 . 5598 . 1623–6 . 2002 . 12446911 . 10.1126/science.1076164 . 2002Sci...298.1623D . 36392120 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Yamamoto K, Yamamoto M, Hanada K, etal . Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. . Mol. Cell. Biol. . 24 . 14 . 6338–49 . 2004 . 15226435 . 10.1128/MCB.24.14.6338-6349.2004 . 434256 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Percipalle P, Fomproix N, Cavellán E, etal . The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. . EMBO Rep. . 7 . 5 . 525–30 . 2006. 16514417 . 10.1038/sj.embor.7400657 . 1479564 .

Notes and References

1. Seither P, Coy JF, Pouska A, Grummt I . Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I . Mol Gen Genet . 255 . 2 . 180–6 . Aug 1997 . 9236775 . 10.1007/s004380050487 . 21286746 .
2. Web site: Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa.