DNA polymerase nu explained

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.^[1] It is a family A DNA polymerase,^[2] considered to be the least effective of the polymerase enzymes.^[3] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.

Further reading

• Zietlow L, Smith LA, Bessho M, Bessho T . Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links . Biochemistry . 48 . 49 . 11817–24 . December 2009 . 19908865 . 2790558 . 10.1021/bi9015346 .
• Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C . Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest . Molecular and Cellular Biology . 26 . 9 . 3527–40 . May 2006 . 16611994 . 1447421 . 10.1128/MCB.26.9.3527-3540.2006 .
• Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD . DNA polymerase POLN participates in cross-link repair and homologous recombination . Molecular and Cellular Biology . 30 . 4 . 1088–96 . February 2010 . 19995904 . 2815579 . 10.1128/MCB.01124-09 .
• Marini F, Kim N, Schuffert A, Wood RD . POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 . The Journal of Biological Chemistry . 278 . 34 . 32014–9 . August 2003 . 12794064 . 10.1074/jbc.M305646200 . free .
• Arana ME, Takata K, Garcia-Diaz M, Wood RD, Kunkel TA . A unique error signature for human DNA polymerase nu . DNA Repair . 6 . 2 . 213–23 . February 2007 . 17118716 . 1950682 . 10.1016/j.dnarep.2006.09.012 .
• Göhler T, Sabbioneda S, Green CM, Lehmann AR . ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage . The Journal of Cell Biology . 192 . 2 . 219–27 . January 2011 . 21242293 . 3172178 . 10.1083/jcb.201008076 .
• Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS . Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links . Chemical Research in Toxicology . 23 . 3 . 689–95 . March 2010 . 20102227 . 2838406 . 10.1021/tx900449u .
• Arana ME, Potapova O, Kunkel TA, Joyce CM . Kinetic analysis of the unique error signature of human DNA polymerase ν . Biochemistry . 50 . 46 . 10126–35 . November 2011 . 22008035 . 3235957 . 10.1021/bi201197p .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase nu

Notes and References

1. Web site: Entrez Gene: Polymerase (DNA directed) nu.
2. Marini F, Kim N, Schuffert A, Wood RD . POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 . The Journal of Biological Chemistry . 278 . 34 . 32014–9 . August 2003 . 12794064 . 10.1074/jbc.M305646200 . free .
3. Web site: UniProtKB - Q7Z5Q5 (DPOLN_HUMAN). Uniprot. 5 July 2018.