POLK explained

DNA polymerase kappa is a DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.^{[1] [2] [3]}

Further reading

• Bavoux C, Hoffmann JS, Cazaux C . Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa . Biochimie . 87 . 7 . 637–46 . 2005 . 15989980 . 10.1016/j.biochi.2005.02.007 .
• Ogi T, Kato T, Kato T, Ohmori H . Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB . Genes Cells . 4 . 11 . 607–18 . 2000 . 10620008 . 10.1046/j.1365-2443.1999.00289.x . 6554870 . free .
• Johnson RE, Prakash S, Prakash L . The human DINB1 gene encodes the DNA polymerase Polθ . Proc. Natl. Acad. Sci. U.S.A. . 97 . 8 . 3838–43 . 2000 . 10760255 . 10.1073/pnas.97.8.3838 . 18103 . 2000PNAS...97.3838J . free .
• Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC . Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene . J. Biol. Chem. . 276 . 1 . 92–8 . 2001 . 11024016 . 10.1074/jbc.M004413200 . free .
• Haracska L, Unk I, Johnson RE, etal . Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA . Mol. Cell. Biol. . 22 . 3 . 784–91 . 2002 . 11784855 . 10.1128/MCB.22.3.784-791.2002 . 133560 .
• Washington MT, Johnson RE, Prakash L, Prakash S . Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini . Proc. Natl. Acad. Sci. U.S.A. . 99 . 4 . 1910–4 . 2002 . 11842189 . 10.1073/pnas.032594399 . 122293 . 2002PNAS...99.1910W . free .
• Suzuki N, Ohashi E, Kolbanovskiy A, etal . Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene) . Biochemistry . 41 . 19 . 6100–6 . 2002 . 11994005 . 10.1021/bi020049c .
• Fischhaber PL, Gerlach VL, Feaver WJ, etal . Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides . J. Biol. Chem. . 277 . 40 . 37604–11 . 2002 . 12145297 . 10.1074/jbc.M206027200 . free .
• Bergoglio V, Bavoux C, Verbiest V, etal . Localisation of human DNA polymerase kappa to replication foci . J. Cell Sci. . 115 . Pt 23 . 4413–8 . 2003 . 12414988 . 10.1242/jcs.00162 . 84437951 .
• Haracska L, Prakash L, Prakash S . Role of human DNA polymerase κ as an extender in translesion synthesis . Proc. Natl. Acad. Sci. U.S.A. . 99 . 25 . 16000–5 . 2003 . 12444249 . 10.1073/pnas.252524999 . 138554 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wolfle WT, Washington MT, Prakash L, Prakash S . Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions . Genes Dev. . 17 . 17 . 2191–9 . 2003 . 12952891 . 10.1101/gad.1108603 . 196459 .
• Haracska L, Prakash L, Prakash S . A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair . Genes Dev. . 17 . 22 . 2777–85 . 2003 . 14630940 . 10.1101/gad.1146103 . 280626 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Suzuki N, Itoh S, Poon K, etal . Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa . Biochemistry . 43 . 20 . 6304–11 . 2004 . 15147214 . 10.1021/bi0360298 .
• Ohashi E, Murakumo Y, Kanjo N, etal . Interaction of hREV1 with three human Y-family DNA polymerases . Genes Cells . 9 . 6 . 523–31 . 2005 . 15189446 . 10.1111/j.1356-9597.2004.00747.x . 24470762 .
• Washington MT, Minko IG, Johnson RE, etal . Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ . Mol. Cell. Biol. . 24 . 13 . 5687–93 . 2004 . 15199127 . 10.1128/MCB.24.13.5687-5693.2004 . 480884 .
• Uljon SN, Johnson RE, Edwards TA, etal . Crystal structure of the catalytic core of human DNA polymerase kappa . Structure . 12 . 8 . 1395–404 . 2005 . 15296733 . 10.1016/j.str.2004.05.011 . free .

Notes and References

1. Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H . Error-prone bypass of certain DNA lesions by the human DNA polymerase κ . Genes Dev . 14 . 13 . 1589–94 . Aug 2000 . 10887153 . 316741 . 10.1101/gad.14.13.1589 .
2. Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC . Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily . Proc Natl Acad Sci U S A . 96 . 21 . 11922–7 . Nov 1999 . 10518552 . 18388 . 10.1073/pnas.96.21.11922 . 1999PNAS...9611922G . free .
3. Web site: Entrez Gene: POLK Polymerase (DNA directed) kappa.