POLE4 explained

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.^[1]

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.^[1]

Further reading

• Post SM, Tomkinson AE, Lee EY . Eva Y.-H. P. Lee . The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon . Nucleic Acids Res. . 31 . 19 . 5568–75 . 2003 . 14500819 . 206465 . 10.1093/nar/gkg765.
• Li Y, Pursell ZF, Linn S . Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon . J. Biol. Chem. . 275 . 30 . 23247–52 . 2000 . 10801849 . 10.1074/jbc.M002548200 . free .
• Wang YL, Faiola F, Xu M, Pan S, Martinez E . Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein . J. Biol. Chem. . 283 . 49 . 33808–15 . 2008 . 18838386 . 2590711 . 10.1074/jbc.M806936200 . free .

Notes and References

1. Web site: Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit.