POLE3 explained
DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[1] [2] [3]
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][4]
Interactions
POLE3 has been shown to interact with SMARCA5.
Further reading
- Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
- Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
- Bolognese F, Imbriano C, Caretti G, Mantovani R . Cloning and characterization of the histone-fold proteins YBL1 and YCL1. . Nucleic Acids Res. . 28 . 19 . 3830–8 . 2000 . 11000277 . 10.1093/nar/28.19.3830 . 110757 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Post SM, Tomkinson AE, Lee EY . Eva Y.-H. P. Lee . The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. . Nucleic Acids Res. . 31 . 19 . 5568–75 . 2003 . 14500819 . 10.1093/nar/gkg765 . 206465 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Li Y, Pursell ZF, Linn S . Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon . J Biol Chem . 275 . 30 . 23247–52 . Aug 2000 . 10801849 . 10.1074/jbc.M002548200 . free .
- Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD . HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins . EMBO J . 19 . 13 . 3377–87 . Oct 2000 . 10880450 . 313940 . 10.1093/emboj/19.13.3377 .
- Web site: Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit).
- Web site: Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit).
