POLDIP3 explained

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.^{[1] [2]}

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.^[2]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.^[3]

Further reading

• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Hirosawa M, Nagase T, Murahashi Y, etal . Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. . DNA Res. . 8 . 1 . 1–9 . 2001 . 11258795 . 10.1093/dnares/8.1.1 . 10.1.1.321.2497 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Collins JE, Goward ME, Cole CG, etal . Reevaluating human gene annotation: a second-generation analysis of chromosome 22. . Genome Res. . 13 . 1 . 27–36 . 2003 . 12529303 . 10.1101/gr.695703 . 430954 .
• Richardson CJ, Bröenstrup M, Fingar DC, etal . SKAR is a specific target of S6 kinase 1 in cell growth control. . Curr. Biol. . 14 . 17 . 1540–9 . 2005 . 15341740 . 10.1016/j.cub.2004.08.061 . free . 2004CBio...14.1540R .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Smyk A, Szuminska M, Uniewicz KA, etal . Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth. . FEBS J. . 273 . 20 . 4728–41 . 2006 . 16984396 . 10.1111/j.1742-4658.2006.05477.x . free .

Notes and References

1. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY . Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen . J Biol Chem . 278 . 12 . 10041–7 . Mar 2003 . 12522211 . 10.1074/jbc.M208694200 . free .
2. Web site: Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3.
3. Richardson . Celeste J . Bröenstrup Mark . Fingar Diane C . Jülich Kristina . Ballif Bryan A . Gygi Steven . Blenis John . Sep 2004 . SKAR is a specific target of S6 kinase 1 in cell growth control . Curr. Biol. . 14 . 17 . 1540–9 . England. 0960-9822. 15341740 . 10.1016/j.cub.2004.08.061 . free . 2004CBio...14.1540R .