POLD4 explained

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene.^[1] It is a component of the DNA polymerase delta complex.

Further reading

• Xie B, Mazloum N, Liu L, etal . Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme. . Biochemistry . 41 . 44 . 13133–42 . 2002 . 12403614 . 10.1021/bi0262707.
• Selak N, Bachrati CZ, Shevelev I, etal . The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. . Nucleic Acids Res. . 36 . 16 . 5166–79 . 2008 . 18682526 . 10.1093/nar/gkn498 . 2532730.
• Bae SH, Bae KH, Kim JA, Seo YS . RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. . Nature . 412 . 6845 . 456–61 . 2001 . 11473323 . 10.1038/35086609 . 4337704 .
• Matsumoto Y, Kim K, Hurwitz J, etal . Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins. . J. Biol. Chem. . 274 . 47 . 33703–8 . 1999 . 10559261 . 10.1074/jbc.274.47.33703. free .
• Liu G, Warbrick E . The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. . Biochem. Biophys. Res. Commun. . 349 . 1 . 360–6 . 2006 . 16934752 . 10.1016/j.bbrc.2006.08.049 .
• Tsurimoto T, Shinozaki A, Yano M, etal . Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. . Genes Cells . 10 . 1 . 13–22 . 2005 . 15670210 . 10.1111/j.1365-2443.2004.00812.x . 24977510 .
• Wood RD, Shivji MK . Which DNA polymerases are used for DNA-repair in eukaryotes? . Carcinogenesis . 18 . 4 . 605–10 . 1997 . 9111189 . 10.1093/carcin/18.4.605. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Huang QM, Akashi T, Masuda Y, etal . Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells. . Biochem. Biophys. Res. Commun. . 391 . 1 . 542–6 . 2010 . 19931513 . 10.1016/j.bbrc.2009.11.094 .
• Li H, Xie B, Zhou Y, etal . Functional roles of p12, the fourth subunit of human DNA polymerase delta. . J. Biol. Chem. . 281 . 21 . 14748–55 . 2006 . 16510448 . 10.1074/jbc.M600322200 . free .
• Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY . Identification of a fourth subunit of mammalian DNA polymerase delta. . J. Biol. Chem. . 275 . 25 . 18739–44 . 2000 . 10751307 . 10.1074/jbc.M001217200 . free .

Notes and References

1. Web site: Entrez Gene: polymerase (DNA-directed).