POLD3 explained

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.^{[1] [2]} It is a component of the DNA polymerase delta complex.

Interactions

POLD3 has been shown to interact with PCNA.^{[3] [4]}

Further reading

• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . free .
• Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY . DNA polymerase delta is involved in the cellular response to UV damage in human cells . J. Biol. Chem. . 269 . 19 . 13748–51 . 1994 . 10.1016/S0021-9258(17)36709-1 . 7910606 . free .
• Longley MJ, Pierce AJ, Modrich P . DNA polymerase delta is required for human mismatch repair in vitro . J. Biol. Chem. . 272 . 16 . 10917–21 . 1997 . 9099749 . 10.1074/jbc.272.16.10917 . free .
• Mo J, Liu L, Leon A, Mazloum N, Lee MY . Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA . Biochemistry . 39 . 24 . 7245–54 . 2000 . 10852724 . 10.1021/bi0000871 .
• Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P . Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta . J. Biol. Chem. . 276 . 52 . 49258–66 . 2002 . 11595739 . 10.1074/jbc.M106990200 . free .
• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . J. Biol. Chem. . 277 . 43 . 40362–7 . 2002 . 12171929 . 10.1074/jbc.M206194200 . free .
• Pohler JR, Otterlei M, Warbrick E . An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit . BMC Mol. Biol. . 6 . 17 . 2006 . 16000169 . 1187890 . 10.1186/1471-2199-6-17 . free .
• Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y . Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase . Biochim. Biophys. Acta . 1764 . 9 . 1447–53 . 2006 . 16935576 . 10.1016/j.bbapap.2006.06.015 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K . Dynamics of human replication factors in the elongation phase of DNA replication . Nucleic Acids Res. . 35 . 20 . 6904–16 . 2007 . 17932049 . 2175312 . 10.1093/nar/gkm822 .

Notes and References

1. Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G . Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts . Nucleic Acids Res . 27 . 10 . 2108–14 . Jun 1999 . 10219083 . 148430 . 10.1093/nar/27.10.2108 .
2. Web site: Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit.
3. Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P . Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta . J. Biol. Chem. . 276 . 52 . 49258–66 . Dec 2001 . 11595739 . 10.1074/jbc.M106990200 . free .
4. Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . J. Biol. Chem. . 277 . 43 . 40362–7 . Oct 2002 . 12171929 . 10.1074/jbc.M206194200 . free .